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Cardiovascular diseases treatment in projects of Pharmahungary Group

Cardiovascular diseases treatment in projects of Pharmahungary Group

Publish date: 2013-01-08

The Hungarian Pharmahungary Group is a strong company that provides preclinical and clinical R&D services. Their specialization is cardiovascular and metabolic diseases treatment. But, in fact, what did they achive to be proud of?

Tags: pharma , hungary

Well, apart from outsourcing, as a part of their work they created four projects open for out-licensing and co-development partnership.

The first and most advanced project concerning BiglycansTM is now in the pre-clinical development and it is expected to be moved into phase I clinical trials in up to 3 years time. BiglycansTM are small leucine-rich repeat proteoglycan (SLRP), they are found  in a variety of extracellular matrix tissues such as bone, cartilage and tendon. Pharmahungary Group project concern their usage in preparation of pharmaceutical compositions of anti-atherosclerotic and anti-ischemic preparations. Therefore BiglycansTM are planned to be able to take part in treatment of atheriosclerosis, acute myocardial infraction and as cytoprotection.

The miRNA therapy project is another one in quite advanced state as it is now in the phase of pre-clinical research. In course of work the miRNA (small RNA molecule taking part in post-transcriptional regulation of gene expression) useful for cytoprotection in ischemic diseases were selected in addition to preparation the method of identification suitable for cytoprotective miRNA called “proteomiRs”.

At the similar stage of advancement we may find the statin safety project. Statins are the drugs used directly to inhibit the HMG-CoA reductase and therefore to lower the level of cholesterol levels and prevent cardiovascular diseases. As many side effects of statins were found in real world use studies the most concerning one was that their usage reduce endogenous cardioprotection of patient, the project aims in finding endogenous substance that inhibit this side effect and therefore the natural protection system will not be harmed during the statin-based drug therapy.

The last project called MMPharmaTM just entered the pre-clinical research phase. The MMPs are involved in acute ischemia. The studies performed during that project showed that inhibition of MMP-2  is useful in reducing reperfusion injury. The further investigation goes in the direction of selecting small molecules for selective inhibition of MMP 2, 9, 13 and their application.

All of the projects are supported by the publications and exhibits positive forecasts for the future of studies. As the Pharmahungary Group is a strong player in the case of preparing the pharmaceuticals aiming in cardiovascular diseases treatment it is worthy to get familiar with their work.

 

By Maria Rutkiewicz

 

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