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A TALEN(T) for treating leukaemia

A TALEN(T) for treating leukaemia

Publish date: 2015-11-23

Genome editing with the use of TALENs – the artificial restriction enzymes – was employed for the world first time to cure acute lymphoblastic leukaemia. TALENs helped to modify T cells obtained from a healthy donor in order to beat cancer cells, remaining invisible to immune system and immunosuppressive drug.

Tags: genetic engineering , gene therapy , T cells , UCART19 , acute lymphoblastic leukaemia , TALEN , genome editing

TALEN (transcription activator-like effector nuclease) is a modern tool of genetic engineering allowing to introduce precise cuts of DNA strands at virtually any position in a genome. These artificially built enzymes consist of oligopeptide DNA-binding domain of high sequence variability (TAL) and a restriction domain FokI that cuts sequence flanking a binding site. Acting as dimmers, TALENs allow to precisely edit sequences in situ and introduce any type of point mutations, deletions, additions etc.

                  

TALENs was employed to create genetically modified T cells named UCART19, designed to treat acute lymphoblastic leukaemia (ALL). They were designed by Dr. Waseem Qasim from Institute of Child Heath in London, and are manufactured by Cellectis company. Those cells present CAR19 receptor on their surface recognising CD19 antigen specific for altered lymphoblastic B cells – therefore cancer cells can be killed. UCART19 cells, however, are derived not from patient, but from an anonymous donor. Nonetheless, administration of cells does not lead to graft-versus-host disease based on differences in major histocompatibility complex. TALENs were used to eliminate HLA family receptors from T cells’ surface, making them invisible to patient’s immune system as foreign cells. Moreover, UCART19 are insensitive to immunosuppressive drugs. Depletion of another antigen CD52 allows for simultaneous administration of antibodies recognising CD52+ lymphocytes.

Independently on running clinical trials – which results are to be presented in December during American Society of Hematology Annual Meeting – UCART19 must had entered the game earlier. A therapy was applied in Great Ormond Street Hospital in London to 11-month girl suffering from ALL, where all available therapies did not succeed. Layla, diagnosed at her 4th month – following parents’, ethics institution’s and Cellectis agreement – had an experimental therapy administered, as a last chance treatment. Although it will take a year or two to properly evaluate treatment result, the girl is coming back to health. After subsequent bone marrow transplantation, patient’s immune system has rebuilt and removed genetically modified T cells.

This is not the first-in-man case of application of modified T cells to treat ALL. However, this is a first clinical application of TALEN engineered universal CAR19 T cells, in which genes were not only added but edited and removed. This novel strategy enable “off-the-shelf”’ therapy with mismatched donor CAR19 T cells and is a milestone in blood cancer treatment. Hopefully, such approach would be used to treat solid tumors in the near future.

Monika Kossakowska-Zwierucho

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2017-08-05 17:48:48 +0200
Effective LOVE SPELL to Win your Ex-Lover back fast.{obhoosagie@gmail.com or whatapp +233556329035} Hi my name is Kate Clancy, I’m 24 years old. My husband left me 3 months ago, and i love him so much, i have been looking for a way to get him back since then. i have tried many options but he did not come back, so i searched for help online and I came across a website that suggested that Dr Unity can help get ex back fast. So, I felt I should give him a try..I contacted him and he told me what to do and i did it, then he did a (LOVE SPELL) for me, 28 hours later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal.add he up on whatapp +233556329035 me and my husband are living together happily again.. All thanks to Dr Unity.If you have any problem contact Dr.Unity now and i guarantee you that he will help you..Email him at: obhoosagie@gmail.com ,you can also call him or add him on whats-app:+233556329035,obhoosagie@gmail.com
Guest
2017-07-28 13:40:58 +0200
Hi my name is Kate Clancy, I’m 24 years old. My ex boyfriend he broke up with me 5 weeks ago. I’m currently 15 weeks pregnant. We were together for 7 years (engaged the last). The day he broke up with me he said he “wanted to find himself, wanted to be free, and was confused if he still wanted to be with me or not.” I was devastated but was cool and calm because he’s been dealing with depression for 4 years and I think the news of our pregnancy broke him. I knew he was unhappy with himself because he got in a real bad car accident 4 years ago that changed his life. He lost his football scholarship, the chance to go to school, and hasn’t been able to find a job. When he broke up with me he said that he loves me and always will love me. When he decided to split I decided I wouldn’t contact him because he wanted space, but he calls me at least once a day to check on me. At times he offers to do favors for me like being me things when I’m sick and wash my car. I agree to let him do these things for me because I miss him so much and it seems like everytime I see him he still kisses me and tells me he loves me. He still wants to go to all our sons check up and I do invite him to them. I’m trying to be strong but his actions are confusing me. This was the guy I thought I was going to spend the rest of my life with.i was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help get ex back fast. So, I felt I should give him a try. I contacted him and he told me what to do and i did it, then he did a Lover-spell for me. 28 hours later, my bf came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my bf are living together happily again..All thanks to Dr Unity. If you have any problem contact Dr.Unity now and i guarantee you that he will help you..Email him at: Unityspelltemple@gmail.com ,you can also call him or add him on whats-app:+2348071622464 ,his website:http://unityspelltemple.webs.com
Guest
2017-06-28 07:15:30 +0200
This Is How To Actually Win And Get Your Ex Back With The Help Of Dr Happy Powerful And Urgent Love Spell With 100% Guarantee Hiiiii!! my boyfriend and I have been getting into little arguments which then later escalated. A lot of which are my fault but I never thought I would lose him because we are in love. He told me yesterday that he loves me but is done. That the fights keep hurting him too much. I can’t believe I hurt him like that and would love nothing more than another chance to prove to him and myself that I will cut out my insecurities that I’ve brought into this relationship. I did all i could to end this fight between us, didn’t work so i had to seek the help of a spell caster who i met online and promised to help me bring him back into my life in 2 days time. i wasn’t really sure about this, but i was really desperate that i had to do all that the spell caster asked me. it was on the second day at 5pm on Friday, i had a knock on the door and to my greatest surprise, it was my boyfriend, the first thing he said, was that he has forgiven me and he will never leave me again, Am so full of joy for what this spell caster and to this product page and graphic love spell coz it really help and work for me, i also want the world to benefit from this. if you need his help you can reach him for any thing on relationship problem, getting your ex back save and protect your marriage life with your soul mate contact him now for he is so powerful and real. Urgently email him now on happylovespell2@gmail.com for more info Visit or view on his web site at Web site:http://happyspelltemple.webs.com/ Also for quick option on how to help with a love spell add him up on Whats-app +2348133873774
Guest
2017-06-28 07:15:06 +0200
This Is How To Actually Win And Get Your Ex Back With The Help Of Dr Happy Powerful And Urgent Love Spell With 100% Guarantee Hiiiii!! my boyfriend and I have been getting into little arguments which then later escalated. A lot of which are my fault but I never thought I would lose him because we are in love. He told me yesterday that he loves me but is done. That the fights keep hurting him too much. I can’t believe I hurt him like that and would love nothing more than another chance to prove to him and myself that I will cut out my insecurities that I’ve brought into this relationship. I did all i could to end this fight between us, didn’t work so i had to seek the help of a spell caster who i met online and promised to help me bring him back into my life in 2 days time. i wasn’t really sure about this, but i was really desperate that i had to do all that the spell caster asked me. it was on the second day at 5pm on Friday, i had a knock on the door and to my greatest surprise, it was my boyfriend, the first thing he said, was that he has forgiven me and he will never leave me again, Am so full of joy for what this spell caster and to this product page and graphic love spell coz it really help and work for me, i also want the world to benefit from this. if you need his help you can reach him for any thing on relationship problem, getting your ex back save and protect your marriage life with your soul mate contact him now for he is so powerful and real. Urgently email him now on happylovespell2@gmail.com for more info Visit or view on his web site at Web site:http://happyspelltemple.webs.com/ Also for quick option on how to help with a love spell add him up on Whats-app +2348133873774
Guest
2016-12-03 09:13:46 +0100
I am here to share the unexpected miracle that happened to me, My name is LEWIS ARNORD i live in United State,and I`m happily married to a lovely and caring wife,with two kids A very big problem occurred in my family seven months ago between me and my wife so terrible that she took the case to court for a divorce she said that she never wanted to stay with me again,and that she did not love me anymore So she packed out of my house and made me and the children passed through severe pain. I tried all my possible means to get her back after much begging but all to no avail and she confirmed it that she has made her decision,and she never wanted to see me again. So on one evening as i was coming back from work,i met an old friend of mine who asked of my wife So i explained every thing to her,so she told me that the only way i can get my wife back,is to visit a spell caster,because it has really worked for her too So i never believed in spell,but i had no other choice,than to follow her advice. Then she gave me the email address of the spell caster whom she contacted that once help her.(successspells@outlook.com}, So the next morning,i sent an mail to the address she gave to me,and the spell caster assured me that he was going to help me get my wife back to me what an amazing statement!! I never believed,so he spoke with me,and told me everything that i need to do. Then the next morning, So surprisingly for me my wife who have not pick my calls nor reply my messages for the past seven {7}months called me to inform me that she was coming back So Amazing!! So that was how she came back to me and the kids,with lots of love and joy,and she apologized for her mistake,and for the pain she caused me and my children. Then from that day,our relationship is now stronger than how it were before,by the help of a spell caster called Priest Ola . So, i will advice you out there to kindly contact the same spell caster via email (successspells@outlook.com or his website www.successspells.net),if you are in any condition like this,or you have any problem related to "bringing your ex back. So thanks to Priest Ola for bringing back my wife,and brought great joy to my family once again. Thanks..
Guest
2016-11-28 05:26:58 +0100
How To Stop A Divorce And Save Your Marriage By Powerful And Genuine Spell Caster, My name is Herbert Gerhard,I live in Koeln, Germany, I have been married for 4 years now and my wife and i love each other so dearly.It was after 8 years of our marriage, my wife suddenly changed. She was having an affair with a guy outside, and i noticed it.I started praying for divine intervention.The issue became more serious that i have to informed my pastor about it. We prayed, but nothing happened. My wife just came home one day she picked up her things and left me and the kids.At this time i was confused and not knowing what to do again, because i have lost my wife and my marriage too. I was just checking my mails in the office one morning, when i saw someone sharing her testimony on how Dr Love quick solution spell helped her out with her marital problems. So i contacted the email address of Dr Love quick solution spell she posted along side the testimony. I told him about my problems, and he told to be calm ,and that i have come to the right place, that i should fill some information about myself,which i did. It was after 30 minute he called me again congratulating me that my problems will be solved within two days. He told me what went wrong with my wife and how it all happened.That he will restored my marriage.To my greatest surprise, my wife came to my office begging me on her knees second day, that i should find a place in my heart to forgive her.I quickly asked her up ,that i have forgiven her. So my dear friends, your case shouldn't be any difference. It might look so difficult or heart breaking, why don't you give Dr Love quick solution spell a try.Your relationship will also be restored, because i know he will use his spells also to bring back your WIFE or HUSBAND.And if you are sick of any disease,just let him know about it. He will cast a spell to cure you too,he actually cured my uncle of cancer and paralysis.Contact him via ( lovespiritualtemple@gmail.com ) I have introduced him to many of my friends too and they all keep talking good about him. How he helped some to cast spell for good jobs and they got jobs in no time. He does all kinds of spell to solve all sorts of problems. You can contact him on any problems,he is always there to help you.I Can't give out his phone number here,I only give it out when you request for it personally.You can get that from him all by yourself anyway,when you contact him through his email address. His email address one more time is lovespiritualtemple@gmail.com
Guest
2016-11-28 05:26:06 +0100
How To Stop A Divorce And Save Your Marriage By Powerful And Genuine Spell Caster, My name is Herbert Gerhard,I live in Koeln, Germany, I have been married for 4 years now and my wife and i love each other so dearly.It was after 8 years of our marriage, my wife suddenly changed. She was having an affair with a guy outside, and i noticed it.I started praying for divine intervention.The issue became more serious that i have to informed my pastor about it. We prayed, but nothing happened. My wife just came home one day she picked up her things and left me and the kids.At this time i was confused and not knowing what to do again, because i have lost my wife and my marriage too. I was just checking my mails in the office one morning, when i saw someone sharing her testimony on how Dr Love quick solution spell helped her out with her marital problems. So i contacted the email address of Dr Love quick solution spell she posted along side the testimony. I told him about my problems, and he told to be calm ,and that i have come to the right place, that i should fill some information about myself,which i did. It was after 30 minute he called me again congratulating me that my problems will be solved within two days. He told me what went wrong with my wife and how it all happened.That he will restored my marriage.To my greatest surprise, my wife came to my office begging me on her knees second day, that i should find a place in my heart to forgive her.I quickly asked her up ,that i have forgiven her. So my dear friends, your case shouldn't be any difference. It might look so difficult or heart breaking, why don't you give Dr Love quick solution spell a try.Your relationship will also be restored, because i know he will use his spells also to bring back your WIFE or HUSBAND.And if you are sick of any disease,just let him know about it. He will cast a spell to cure you too,he actually cured my uncle of cancer and paralysis.Contact him via ( lovespiritualtemple@gmail.com ) I have introduced him to many of my friends too and they all keep talking good about him. How he helped some to cast spell for good jobs and they got jobs in no time. He does all kinds of spell to solve all sorts of problems. You can contact him on any problems,he is always there to help you.I Can't give out his phone number here,I only give it out when you request for it personally.You can get that from him all by yourself anyway,when you contact him through his email address. His email address one more time is lovespiritualtemple@gmail.com
Guest
2016-11-28 05:25:42 +0100
How To Stop A Divorce And Save Your Marriage By Powerful And Genuine Spell Caster, My name is Herbert Gerhard,I live in Koeln, Germany, I have been married for 4 years now and my wife and i love each other so dearly.It was after 8 years of our marriage, my wife suddenly changed. She was having an affair with a guy outside, and i noticed it.I started praying for divine intervention.The issue became more serious that i have to informed my pastor about it. We prayed, but nothing happened. My wife just came home one day she picked up her things and left me and the kids.At this time i was confused and not knowing what to do again, because i have lost my wife and my marriage too. I was just checking my mails in the office one morning, when i saw someone sharing her testimony on how Dr Love quick solution spell helped her out with her marital problems. So i contacted the email address of Dr Love quick solution spell she posted along side the testimony. I told him about my problems, and he told to be calm ,and that i have come to the right place, that i should fill some information about myself,which i did. It was after 30 minute he called me again congratulating me that my problems will be solved within two days. He told me what went wrong with my wife and how it all happened.That he will restored my marriage.To my greatest surprise, my wife came to my office begging me on her knees second day, that i should find a place in my heart to forgive her.I quickly asked her up ,that i have forgiven her. So my dear friends, your case shouldn't be any difference. It might look so difficult or heart breaking, why don't you give Dr Love quick solution spell a try.Your relationship will also be restored, because i know he will use his spells also to bring back your WIFE or HUSBAND.And if you are sick of any disease,just let him know about it. He will cast a spell to cure you too,he actually cured my uncle of cancer and paralysis.Contact him via ( lovespiritualtemple@gmail.com ) I have introduced him to many of my friends too and they all keep talking good about him. How he helped some to cast spell for good jobs and they got jobs in no time. He does all kinds of spell to solve all sorts of problems. You can contact him on any problems,he is always there to help you.I Can't give out his phone number here,I only give it out when you request for it personally.You can get that from him all by yourself anyway,when you contact him through his email address. His email address one more time is lovespiritualtemple@gmail.com
Guest
2016-11-16 07:14:44 +0100
My lover left me in 2 years ago. he did not contact me, wouldn’t answer my calls and emails, During this period I contacted many casters without results. . But I never lost hope until i got to meet this powerful caster manifestspellcast@ (yahoo). com and he did the most wonderful spell for me and after 3 days everything changed, my lover came back, his love spell works fast even in the most complex circumstances, I am recommending his love spell to every couple who wants to get back together, I can say Dr Manifest possessed all the qualities you want if you want to get your lover back, it was like a dream to me, he will solve your relationship problem.
Guest
2016-10-17 10:42:05 +0200
fix your broken relationship with real love spells that work fast‎!! My boyfriend of a 4yr just broke up with me and am 30 weeks pregnant.I have cried my self to sleep most of the nights and don’t seem to concentrate during lectures sometimes I stay awake almost all night thinking about him and start to cry all over again.Because of this I end up not having energy for my next day’s classes ,my attendance has dropped and am always in uni and on time.Generally he is a very nice guy ,he ended it because he said we were arguing a lot and not getting along.He is right we’ve been arguing during the pregnancy a lot .After the break up I kept ringing him and telling him I will change.I am in love with this guy and he is the best guy I have ever been with.I’m still hurt and in disbelief when he said he didn’t have any romantic feelings towards me anymore that hurt me faster than a lethal syringe.He texts me now and then mainly to check up on how am doing with the pregnancy,he is supportive with it but it’s not fair on me, him texting me as I just want to grieve the pain and not have any stress due to the pregnancy.i was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a spell for me. 28 hours later, my bf came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my bf are living together happily again.. All thanks to Dr Unity. If you have any problem contact Dr.Unity now and i guarantee you that he will help you.Email him at: Unityspelltemple@gmail.com ,you can also call him or add him on whats-app: +2348071622464. Maria Alexander London, UK.
Guest
2016-10-12 06:14:41 +0200
Get your ex lover back between 18 hours urgently{ covenantsolutiontemple@gmail.com}. My name is Mary Lane, today has being the most happiest day of my life after 1 year of sadness and sorrow without being with the one i love. My husband left the house without saying good bye to me because i accused of him for seeing some one else, he left the house with out 2 kids i was hurt and devastated and really needed him back though he cheated in me, i tried all my possible best to make sure to make him come back i tried pleading with his mom {mama lousa} but it never seems to work out well it was like am doing everything in vain. One day a friend of mine on face book posted a comment on facebook on her she got her husband back when he left her and he droped an email of the man that helped her it was Dr Ewan of covenantsolutiontemple@gmail.com, but all thanks to Dr Ewan for coming to change all my worries and sadness to Joy. Then i decided not to waste time i contacted him he told me not to worry that my husband will come back to e in the next 24 hours i believed Dr Ewan so much because i believe he can't fail me and i sent him all my details. Truly Dr Ewan never failed me,my husband who left me for two months came back to me in the next 19 hours . My husband and i have been living happily with our kids since this spell caster reunited us together with his love spells. Thank you so so so much Dr Ewan for your powerful spells. expressions are not sufficient to say thank you. here is his email address covenantsolutiontemple@gmail.com or check out his website https://covenantsolutiontemple.wordpress.com call him or add him on watsapp +2349057353987. Thank you very much Dr i will appreciate you forever.
Guest
2016-10-08 08:11:56 +0200
How to get your Ex-boyfriend/Ex-girlfriend back fast after a break up!! I'm Maria 21 yr old from England, my boyfriend of a 4yr just broke up with me and am 30 weeks pregnant.I have cried my self to sleep most of the nights and don’t seem to concentrate during lectures sometimes I stay awake almost all night thinking about him and start to cry all over again.Because of this I end up not having energy for my next day’s classes ,my attendance has dropped and am always in uni and on time.Generally he is a very nice guy ,he ended it because he said we were arguing a lot and not getting along.He is right we’ve been arguing during the pregnancy a lot .After the break up I kept ringing him and telling him I will change.I am in love with this guy and he is the best guy I have ever been with.I’m still hurt and in disbelief when he said he didn’t have any romantic feelings towards me anymore that hurt me faster than a lethal syringe.He texts me now and then mainly to check up on how am doing with the pregnancy,he is supportive with it but it’s not fair on me, him texting me as I just want to grieve the pain and not have any stress due to the pregnancy.i was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a spell for me. 28 hours later, my bf came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my bf are living together happily again.. All thanks to Dr Unity . If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you.This is his E-mail: Unityspelltemple@gmail.com or add him up on Whats-app: +2348071622464 ,you can also visit his website:http://unityspelltemple.yolasite.com .
Guest
2016-09-20 11:33:51 +0200
!!! “LOVE is the key to LIFE”.DR Ehinome !!! My name is Miss Rose Lisa am from Texas, am a woman who love and cherish my husband more than any other thing you can imagine on earth continent. My husband was so lovely and caring after 3years of marriage he was seriously ill and the doctor confirm and said he has a kidney infection that he needed a kidney donor, that was how I start searching for a good Samaritan who can help,doctor has given me a periodic hour that he will live just 26hours left, that was how I ask the doctor if I can be of help to my husband that was how he carried out the text,the confirming was successful, I was now having this taught that since 3 years now we got married I have not be able to get pregnant can I be able to get bring again? That was the question I ask the doctor, he never answer his response was did you want to lost your husband? I immediately reply no I can't afford to loose him. After the operation my husband came back to live and was healthy I was also OK with the instruction given to me by the doctor, after 3months my husband came home with another lady telling me, that is our new wife that will give us kids and take care of us, that was how I was confused and started crying all day, that was how my husband ran away with his new wife Clarabelle. Since then I was confuse don't no what to do that was how I went back to the doctor and tell him everything, he told me that, this is not just an ordinary it must be a spiritual problem that was how he gave me this email (ehinomespellcaster@gmail.com) that I should tell her all my problem that she can help that was how i contacted her and I do as instructed. After 3days and I have done what she ask me to do, my husband start searching for me and went back to the doctor, that was how we well settle she also told me not to worry that I will get pregnant, this month making it the fifth Month I contacted her am now 3months pregnant. These great spell cater is a great man, if you are any kind of problem you can contact him here on his email (ehinomespellcaster@gmail.com) website address: //ehinomespellcaster.yolasite.com you can also call or text me for questions or anything +447031987255. contact him Via whatsapp+2349039545297.is the best in world trust hem
Guest
2016-09-04 00:38:19 +0200
Best spell caster of the year revealed by google. save your crumbling marriage now. Am Jerry miler, I live in London, and I’m happily married with a lovely wife and three children. I had a very big problem with my wife few months ago, to the extent that she left the house with our kids to her parents' for almost 5 months. All efforts to bring them back proved abortive. Friends and Family were all in concern and my very close mate gave me an advice concerning a spell caster, and he quote; “There’s someone who can handle your situation, he’s always ready and able to do anything related to spiritual matters, I searched for a spell caster on the internet, his advert was everywhere, i found his number and called him on his mobile number +2347052958531. Although I never believed in spell casting, but he convinced me and I had no choice than to follow his advice, because I never dream of losing my lovely wife and I was desperate. So I did all what he told me to do and i did. He told me that I’ll get my wife back in two days after the spell is completed. I was skeptical. He casted the spell for me and i was so anxious waiting to see or hear from her, until the second day when my wife called and said she was coming HOME…..It was like a joke to me!!! That’s how I got my family back through spiritual means and our relationship is now stronger than ever. One of the price I was asked to pay was to tell it to people around me that problems like this, can always be solved by Dr Ewan. And this is his email too if you wish to contact him and solve your problem too covenantsolutiontemple@gmail.com , my advice to you out there is to visit this great Dr Ewan and tell him your problems. He's capable of handling anything spiritual and spell casting. Thanks a lot for saving my marriage. covenantsolutiontemple@gmail.com. You can also add him up on watsapp on +2349057353987 or call him on +2347052958531
Guest
2016-08-31 17:02:36 +0200
Dear friends, my name is SUSAN from united states i had a problem with my boyfriend 2years ago, which lead to our break up. when he broke up with me, i was not my self again, i felt so empty inside me. until a friend of mine told me about a spell caster who helped him in the same problem too. i email Dr UKO the spell caster and i told him my problem and i did what he asked of me, to cut the long story short. before i knew what was happening my boyfriend gave me a call and told me that he was coming back to me in just 2days and was so happy to have him back to me. we have two kids together and we are happy with our selves. thanks to Dr UKO for saving my relationship and for also saving others own too. continue your good work the great spell caster email address : ukospelltemple@yahoo.com / ukospelltemple.wixsite.com/mysite or whatsapp him on ; +2347064650019
Guest
2016-07-03 12:37:28 +0200
!!! “LOVE is the key to LIFE”.DR Ehinome !!! My name Joyce Brown from Florida,i am 50 years old...My life is back!!! After 2 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Ehinome, which i met online. On one faithful day, as I was browsing through the Internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back,some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Ehinome's e-mail address.After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Ehinome, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High ehinomespellcaster@gmail.com anytime, he might be the answer to your problems. Here's his contact: ehinomespellcaster@gmail.com call 2348036345198 or website address: http://ehinomespellcaster.yolasite.com
Guest
2016-07-03 12:37:08 +0200
!!! “LOVE is the key to LIFE”.DR Ehinome !!! My name Joyce Brown from Florida,i am 50 years old...My life is back!!! After 2 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Ehinome, which i met online. On one faithful day, as I was browsing through the Internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back,some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Ehinome's e-mail address.After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Ehinome, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High ehinomespellcaster@gmail.com anytime, he might be the answer to your problems. Here's his contact: ehinomespellcaster@gmail.com call 2348036345198 or website address: http://ehinomespellcaster.yolasite.com
Guest
2016-06-25 16:12:31 +0200
Hi everyone! I'm so excited my husband is back after he have left me for another woman. My husband and I have been married for about 7 yrs now. We were happily married with two kids, a boy and a girl. 3 months ago, I started to notice some strange behavior from him and a few weeks later I found out that my husband is seeing someone. He started coming home late from work, he hardly care about me or the kids anymore, Sometimes he goes out and doesn't even come back home for about 2-3 days. I did all I could to rectify this problem but all to no avail. I became very worried and needed help. As I was browsing through the internet one day, I came across a website that suggested that Dr Unity can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and and told him my problems and he told me what to do and i did it and he did a spell for me. 24 hours later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again.. All thanks to Dr Unity . If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you. This is his E-mail: Unityspelltemple@gmail.com or call him on: +2348072370762. I am Donna Murray by name and i reside here in Silver Springs Florida. My residential address is as follows. 7008 E Hwy 326 Silver Springs Florida 34488, United States.If you have any problem contact him and guarantee you that he will help you.
Guest
2016-06-07 14:43:16 +0200
Hi everyone, I am so excited to share this with you all, about this powerfully and genuine spell caster who save my marriage and brought my husband back to me today. I am Natasha Hayes by name and i reside here in London, United Kingdom. I'm happily married to a lovely and caring husband ,with two kids.A very big problem occurred in my family seven months ago,between me and my husband .so terrible that he took the case to court for a divorce.he said that he never wanted to stay with me again,and that he didn't love me anymore.So he packed out of the house and made me and my children passed through severe pain. I tried all my possible means to get him back,after much begging,but all to no avail.and he confirmed it that he has made his decision,and he never wanted to see me again. So on one evening,as i was coming back from work,i met an old friend of mine who asked of my husband .So i explained every thing to him,so he told me that the only way i can get my husband back,is to visit a spell caster,because it has really worked for him too.So i never believed in spell,but i had no other choice,than to follow his advice. Then he gave me the email address of the spell caster whom he visited.{Unityspelltemple@gmail.com}. So the next morning,i sent a mail to the address he gave to me,and the spell caster assured me that i will get my husband back the next day.What an amazing statement!! I never believed,so he spoke with me,and told me everything that i need to do. Then the next morning, So surprisingly, my husband who didn't call me for the past{7}months,gave me a call to inform me that he was coming back.So Amazing!! So that was how he came back that same day,with lots of love and joy,and he apologized for his mistake,and for the pain he caused me and my children. Then from that day,our marriage was now stronger than how it were before,by the help of a spell caster Dr Unity. So, i will advice you out there, if you have any problem contact Dr Unity and i guarantee you that he will help you and you will be the next to share your testimony to every one in the world!!. Email him at: Unityspelltemple@gmail.com or call him on +2348072370762 and you can also visit his website for more details: http://unityspelltemple.yolasite.com. thanks to Dr Unity please share this with your friends..
Guest
2016-04-07 10:10:59 +0200
My husband and I have been married for about 7 yrs now. We were happily married with two kids, a boy and a girl. 3 months ago, I started to notice some strange behavior from him and a few weeks later I found out that my husband is seeing someone. He started coming home late from work, he hardly care about me or the kids anymore, Sometimes he goes out and doesn't even come back home for about 2-3 days. I did all I could to rectify this problem but all to no avail. I became very worried and needed help. As I was browsing through the internet one day, I came across a website that suggested that Dr Unity can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he did a spell for me. Three days later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again.. All thanks to Dr Unity . If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you. This is his E-mail: Unityspelltemple@gmail.com .
Guest
2016-04-03 03:47:47 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High monicaspiritualtemple@gmail.com anytime, he might be the answer to your problems. Here's his contact: monicaspiritualtemple@gmail.com or call him +2348134493948
Guest
2016-04-03 02:12:40 +0200
'After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: spiritualherbalisthealing@gmail.com or call him +2349055637784 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS'
Guest
2016-03-15 18:25:12 +0100
dr, saviour did some work for me and I saw results fast, even though we did a recast his work is still on point. My husband is home and we are working on our marriage. We still have our ups and downs but we are still together. Sometimes we need to have just a little faith along with the dr, saviour help and things will work out fine. I will be using his service for our business. If you are searching for help and not sure who to trust him , via email: {dr.saviour12@gmail.com} words will not be enough to appreciate what he has done for me. i have promised to share the good news
Guest
2016-02-25 01:10:42 +0100
My life became devastated when my husband sent me packing, after 8 years that we have been together. I was lost and helpless after trying so many ways to make my husband take me back. One day at work, i was absent minded not knowing that my boss was calling me, so he sat and asked me what its was all about i told him and he smiled and said that it was not a problem. I never understand what he meant by it wasn't a problem getting my husband back, he said he used a spell to get his wife back when she left him for another man and now they are together till date and at first i was shocked hearing such thing from my boss. He gave me an email address of the great spell caster who helped him get his wife back, i never believed this would work but i had no choice that to get in contact with the spell caster which i did, and he requested for my information and that of my husband to enable him cast the spell and i sent him the details, but after two days, my mom called me that my husband came pleading that he wants me back, i never believed it because it was just like a dream and i had to rush down to my mothers place and to my greatest surprise, my husband was kneeling before me pleading for forgiveness that he wants me and the kid back home, then i gave Happy a call regarding sudden change of my husband and he made it clear to me that my husband will love me till the end of the world, that he will never leave my sight. Now me and my husband is back together again and has started doing pleasant things he hasn't done before, he makes me happy and do what he is suppose to do as a man without nagging. Please if you need help of any kind, kindly contact Happy for help and you can reach him via email: happylovespell2@gmail.com
Guest
2016-01-03 07:01:12 +0100
Glorious be Unto Dr Ukaka the great man and ever, my name is Sarah from Florida city usa. since 1 and a half year I have witness what is called heart broken. my boyfriend that promised me marriage failed me and impregnate me and leave,he dump me,he stop calling" he stop picking my calls,and he no longer respond to me. I have be looking for solution,I fall into the hands of fake spell caster,they rough me off and took my money without help.I have cried,I have weep"and tears runs out of eyes. The silentness in my heart brought me to the deepest path of failure that I lost my job. Crying all day,because of my life was lonely. So thanks to Ukaka that came into my life and brought me the greatest joy that was lost. I saw his mail while browsing and I contact and tell him what I am passing through with no doubt because what saw about him,was enough to believe. And I was given words of solution on what to do. I can't really help thinking about it I have tried to see what I can do, I manage to provide him some materials and he help me with the rest,after casting the spell, 12hrs later he came with rose on his hand and I was even about going out,i saw him in front of my door when he sees me he knee and said he is dying I should forgive him and accept him back he was crying,I can't wait to let him finish I quickly crab him and kiss him, just then" he said he is restless without me, just as the prophet has said he will be. He brought out a ring and put it on my hand. Our wedding day was scheduled,1week after we got married. today makes it 2weeks and we are living happily I don't know how to praise him enough, he has done me a thing I can never forget. And I can't really share to myself alone, I want y'all to help me praise him because if it is wasn't for him I already plan of committing suicide. But right now I am now so happy more than I was before. And you out there crying for help you've already got one,Ukaka is the man that you need in all rampart. contact his address if you need his service, freedomlovespell@hotmail.com also contact him on his web site: freedomlovespelltemple.yolasite.com
Guest
2015-12-30 09:29:10 +0100
Marriage restoration.. I lost my husband to another woman 2 weeks ago after 27 years of marriage . We had a lovely marriage but he started a relationship with a co worker who chased after him . He is living away near his work and her and refuses to talk to me or to come home . I am devastated and am finding it hard to cope . I wish I did not love him and that I could move on but I can't . I don't know how to stop feeling like this I wish I didn't as its eating me away and I m starting to feel ill. I have degraded myself begging him to come home all to no avail. I became very worried and needed help. As I was browsing through the internet one day, I came across a website that suggested that Dr Frank Ojo can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he did a spell for me. tow days later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again.. All thanks to Dr Frank Ojo . If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you. if you have any problem contact him, I give you 100% guarantee that he will help you, This is his details, E-mail: Templeofloveandprosperity@gmail.com , Web site: http://lovespell2.yolasite.com . Mobile number +2348072370762. Thank you all for reading.
Guest
2015-12-30 09:29:01 +0100
Marriage restoration.. I lost my husband to another woman 2 weeks ago after 27 years of marriage . We had a lovely marriage but he started a relationship with a co worker who chased after him . He is living away near his work and her and refuses to talk to me or to come home . I am devastated and am finding it hard to cope . I wish I did not love him and that I could move on but I can't . I don't know how to stop feeling like this I wish I didn't as its eating me away and I m starting to feel ill. I have degraded myself begging him to come home all to no avail. I became very worried and needed help. As I was browsing through the internet one day, I came across a website that suggested that Dr Frank Ojo can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he did a spell for me. tow days later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again.. All thanks to Dr Frank Ojo . If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you. if you have any problem contact him, I give you 100% guarantee that he will help you, This is his details, E-mail: Templeofloveandprosperity@gmail.com , Web site: http://lovespell2.yolasite.com . Mobile number +2348072370762. Thank you all for reading.
Guest
2015-12-12 11:25:35 +0100
Hi everyone, I'm testify how i Got my Husband back after a Divorce !!! I'm Tiffany Wilson From California, after Five years of marriage, My Husband divorces me off no reason, I cried all through and try all the possible best I could to make everything work out for good and to get him back but to no avail, I was confused and frustrated until I crossed a site of Dr Frank Ojo, I read everything completely on the site, it was talking about Love spells and reunion marriage spells and different types of spells, I was more confused on what to do because I don’t believe on spell casters mostly on Love spells, though I decided to give a try out, I contacted Dr Frank Ojo and explained everything completely to him on what I am passing through to my own greatest surprise, Dr Frank Ojo told me that my husband is going to call me back to come home after two days he has finished casted the spell. I have believed on him and so surprising really my husband calls me back home and ask for forgiveness and he promised to Love me only and forever be with me only. All great thanks to Dr Frank Ojo for his marvelous spell work, contact him today by his Email: Templeofloveandprosperity@gmail.com ,website info: http://lovespell2.yolasite.com , If you have any problem contact him, I give you 100% guarantee that he will help you, Thanks to Dr Frank Ojo.
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