AURELIA is a study that involves women with recurrence of platinum-resistant ovarian cancer. As a result of the phase 3 study addition of the Avastin to the anticancer therapy have clinical meaning - it extend the progression free survival.
Platinum-resistant ovarian cancer is very dangerous and progressive because it gives the recurrence very fast (mean time without recurrence about 3.4 months). During clinical studies Avastin elongates this time to 6.7 months.
Specialists still do not know why this type of cancer is platinum resistant, for now, there is no effective cure. Avastin registration by European Commission (EC) will enable its usage with combination of paclitaxel, topotecan, or pegylated liposomal doxorubicin and extends the survival rate without cancer progression. Avastin is first biologic drug approved by EC in the treatment of platinum-resistant ovarian cancer.
Ovarian cancer is cancer developed from ovarian cells, that have ability to spread not only to other parts of gynecological system, but also to give metastasis to another parts of the body. In early onset it gives no special symptoms. Among the risk factors are hormone replacement therapy, but from the other hand birth control decrease the risk. It is all about the ovulation, women that ovulate more frequent and without break (therefore those who never had children) are in higher risk. The risk rises also within those that carry a mutations in BRCA1 and BRCA2.
In European Union(EU) are diagnosed about 44 thousands recurrence every year in women with ovarian cancer. Within those patients with initial treatment about 10 000 will show the platinum resistant type of tumor per year. General statistics says that in 2011 more than 7 thousands of women in UK were diagnosed with ovarian cancer, barely 4300 died. Over 2005 – 2009 only 42,9 % survived the ovarian cancer in England. For now it has the highest mortality rate of all gynecological cancers.
2016-04-03 03:16:42 +0200
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