When oncogenes are activated inside a cell, they normally mobilise neoplasm suppressor networks which can act like a brake to cancer through a process termed oncogene-induced senescence (OIS). They depart proliferating cells almost irreversibly, ensuring protection against vicious transformation. Now, a research team led by Daniel Peeper from the Netherland’s Cancer Institute in Amsterdam has identified a metabolic gate-keeper of the process.
Using metabolic and functional analyses of melanoma cells carrying the common BRAFV600E mutation, the team of Dutch, Scottish, Belgian, Spanish, Israeli and US scholars identified the TCA enzyme pyruvate dehydrogenase (PDH) as arevelant mediator of cancer senescence. BRAFV600E-entailed senescence was accompanied by simultaneous suppression of the PDH-inhibitory enzyme pyruvate dehydrogenase kinase 1 (PDK1) and induction of the PDH-activating enzyme pyruvate dehydrogenase phosphatase 2 (PDP2). The total combined activation of PDH enhanced the use of pyruvate in the tricarboxylic acid cycle, causing increased respiration and redox stress.
Exacted standardization of either PDK1 or PDP2 expression horizon inhibited PDH and abrogated oncogene-induced senescence. Diminution of PDK1 eradicated melanoma subpopulations proof to targeted BRAF inhibition, and caused regression of established melanomas. The results suggest a mechanistically new therapeutic way to induce cancer senescence and stop growth cell proliferation at its earliest stages.
Source: http://www.eurobiotechnews.eu [http://www.eurobiotechnews.eu/news/news/2013-02/metabolic-gatekeeper-to-cancer-senescence.html]
edited by Agnieszka Dąbrowska
Guest
2020-05-07 10:30:54 +0200
How I Got My Ex Husband Back...........
I am Shannon by name. Greetings to every one that is reading this testimony. I have been rejected by my husband after three(3) years of marriage just because another woman had a spell on him and he left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address Makospelltemple@yahoo.com , have help a woman to get back her husband and i gave him a reply to his address and he told me that a woman had a spell on my husband and he told me that he will help me and after 2 days that i will have my husband back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my husband. Thanks for Dr.Mako. His email: Makospelltemple@yahoo.com OR.His WhatsApp Number:+2347054263874.
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Guest
2020-03-16 21:44:38 +0100
I came across many testimonies on net testifying of Dr winner a voodoo spell caster that will help you cast a LOTTERY spell and give you the rightful numbers to win the lottery, I didn't believe it, at first but as life got badder i decided to take a try, now my try has made me a millionaire, i have been playing all types of lottery since 7 years now but i have not win up to $1000,after contacting him he cast the spell and give me the hot figures behold i won( FIFTY MILLIONS DOLLARS) now i am a living testimony of the good works of Dr winner A gifted man with a great powers, it is my secret but i decided to make the world known to it as it might be a help to any one who is interested, this happens last week ago you are free to contact him or via Email: Winnersspellcast@gmail.com or via his website:https://winnersspellcast.blogspot.com or his whatsapp +2348138289852
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Guest
2020-01-12 13:23:06 +0100
What a wonderful and a straight forward spell caster that has brought back joy and happiness into my life! Am giving this testimony because am so happy, I want to thank Dr. Iwisa for the great thing He has done in my life , He brought happiness back to my life, I never believed in spell casters until my life fell apart when my lover of 6 years decided to call it quit almost when we wanted to get married. I was so emotional breakdown to the extent i could not do anything reasonable again, after 2months in pain before an old friend of mine introduced me to a spell caster on line called Dr Iwisa, this was after I have been scammed by various fake spell casters. I was introduced me to Dr Iwisa a true Spell Caster. In less than 24 hours i saw wonders, my lover came back to me and my life got back just like a completed puzzle, and after 1month later we got married and it was just like a dream to me because i thought i had lost him forever. Thank you Dr. iwisa for helping me but most of all, Your Honesty and Fast Accurate Results. email: superiorspellhome@gmail.com WhatsApp +27730886631 Website: www.superiorspellhome.com
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Guest
2020-01-12 13:20:23 +0100
What a wonderful and a straight forward spell caster that has brought back joy and happiness into my life! Am giving this testimony because am so happy, I want to thank Dr. Iwisa for the great thing He has done in my life , He brought happiness back to my life, I never believed in spell casters until my life fell apart when my lover of 6 years decided to call it quit almost when we wanted to get married. I was so emotional breakdown to the extent i could not do anything reasonable again, after 2months in pain before an old friend of mine introduced me to a spell caster on line called Dr Iwisa, this was after I have been scammed by various fake spell casters. I was introduced me to Dr Iwisa a true Spell Caster. In less than 24 hours i saw wonders, my lover came back to me and my life got back just like a completed puzzle, and after 1month later we got married and it was just like a dream to me because i thought i had lost him forever. Thank you Dr. iwisa for helping me but most of all, Your Honesty and Fast Accurate Results. email: superiorspellhome@gmail.com WhatsApp +27730886631 Website: www.superiorspellhome.com
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Guest
2020-01-11 01:15:13 +0100
What a wonderful and a straight forward spell caster that has brought back joy and happiness into my life! Am giving this testimony because am so happy, I want to thank Dr. Iwisa for the great thing He has done in my life , He brought happiness back to my life, I never believed in spell casters until my life fell apart when my lover of 6 years decided to call it quit almost when we wanted to get married. I was so emotional breakdown to the extent i could not do anything reasonable again, after 2months in pain before an old friend of mine introduced me to a spell caster on line called Dr Iwisa, this was after I have been scammed by various fake spell casters. I was introduced me to Dr Iwisa a true Spell Caster. In less than 24 hours i saw wonders, my lover came back to me and my life got back just like a completed puzzle, and after 1month later we got married and it was just like a dream to me because i thought i had lost him forever. Thank you Dr. iwisa for helping me but most of all, Your Honesty and Fast Accurate Results. email: superiorspellhome@gmail.com WhatsApp +27730886631 Website: www.superiorspellhome.com
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Ericam
2019-10-12 08:51:42 +0200
Get rid of Cold Sores, unexpected Outbreak and Herpes Virus? then you don't have to keep waiting for treatment when the is a herbal medicine that cure this virus. I was searching online for Herbal Cure for Herpes Virus when I saw a testimony online about Dr. Akintunde and how he cured a lady of HSV1 with his.
natural herbal medicine and tested Negative and in less than a month she was cured of this virus. So it took me time to believe that this was true, because my family Doctor tried all his best to get rid of this virus in my body system but yet no cure and I suffered from outbreak and Cold Sores always. I had to contact Dr. Akintunde after I have access his website and i had faith in God that I was going to be fine and free of this virus one day. Finally I contacted Dr. Akintunde on his WhatsApp number that I saw on the testimony post online, and after our conversation the Doctor only promise me that I was going to be cured and free of this virus after taking his natural herbal medicine because I was tired of my situation with this virus it was so distracting to my life and whole family. Later Dr. Akintunde send some Herbal medicine to me through UPS courier service, with instructions on how to used this medicine, to my biggest surprise first week of taking my herbal medication I saw great improvement and I still think that it's a dream but this is real, I now test Negative of this virus today and my blood pressure well regulated now, my family doctor after my test was extremely surprise to see my test result change to HSV1 Negative and no more symptoms, cold sores, sores throat and outbreak again. I wish to tell everyone about this, mostly if you have this virus then do yourself good to contact Dr. Akintunde and see what the Lord can do through this Herbal Doctor's medicine in less than a month. 100% free from herpes Virus. I and my family say "thank you" Sir, for helping my life. You are a blessing to this generation and God will reward you richly
Dr. Via Email : drakintundehomecare@gmail.com
WhatsApp number: +234 703 524 5593
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Guest
2019-07-28 02:14:36 +0200
Hi everyone I'm Carolina peter and am here to share the wonderful work Dr tunde did for me. After 4 years in marriage with my husband with 2 kids, my husband started acting weird and going out with other women and showed me cold love, on several occasions he threatens to divorce me if I dare question him about his affair with other women, I was totally devastated and confused until a old friend of mine told me about a spell caster on the internet called Dr. tunde who help people with relationship and marriage problem by the powers of love spells, at first I doubted if such thing ever exists but decided to give it a try, when I contact him, he helped me cast a love spell and within 48hours my husband come back to me and started apologizing, now he has stopped going out with other women and his with me for good and for real. Contact this great love spell caster for your relationship or marriage problem to be solved today via email: babatundesolutioncentre1@gmail.com or call or whatsapp:+2348143581382 Also specialize in treating all kinds of illness, HERPES VIRUS, HEPATITIS B, CANCER, BRAIN DISEASE, INFERTILITY, DIABETES AND MORE.
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Guest
2019-07-28 02:14:35 +0200
Hi everyone I'm Carolina peter and am here to share the wonderful work Dr tunde did for me. After 4 years in marriage with my husband with 2 kids, my husband started acting weird and going out with other women and showed me cold love, on several occasions he threatens to divorce me if I dare question him about his affair with other women, I was totally devastated and confused until a old friend of mine told me about a spell caster on the internet called Dr. tunde who help people with relationship and marriage problem by the powers of love spells, at first I doubted if such thing ever exists but decided to give it a try, when I contact him, he helped me cast a love spell and within 48hours my husband come back to me and started apologizing, now he has stopped going out with other women and his with me for good and for real. Contact this great love spell caster for your relationship or marriage problem to be solved today via email: babatundesolutioncentre1@gmail.com or call or whatsapp:+2348143581382 Also specialize in treating all kinds of illness, HERPES VIRUS, HEPATITIS B, CANCER, BRAIN DISEASE, INFERTILITY, DIABETES AND MORE.
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Guest
2018-10-08 16:41:15 +0200
After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: spiritualherbalisthealing@gmail.com or call him +2348164728160 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS
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2018-02-24 18:59:21 +0100
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Waynemark
2017-08-18 18:25:45 +0200
He heals and solve most of the problems & sickness which are failed to be healed by other doctors/healers. He solve bad luck, pregnancy problems, lost lover, sexual weakness, early ejaculation, witch-crafts, broken marriage, poverty, debts trouble, divorce, court cases, domestic problems, gambling losses, Lost jobs, promotions at work, Do you need penis enlargement? Do you want to be Rich? Do you need many children? Are you tired of jealousy people, Evil dreams, all long illnesses, blood pressure, HIV & aids, skin infections? etc. He use strong herbs & magic spells as well as powerful ancestors. Get healed today by this greatest miracle doctor who has healed many people through his experienced ancestors. Join the rest of the world to cerebrate his miracle healings. he can even read and tell you your problems before you say anything to him. He can connect you to talk to the spirit of a deceased of your family member or friend. he can also tell you your future through reading palm, play card, a mirror/water. He uses many ways of healing just to make sure that he certify his clients all over the world. he is the only traditional healer who does fully corresponds with all religious beliefs. contact him on his email address at babaka.wolf@gmail.com or Facebook at priestly.babaka
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Guest
2017-08-02 19:31:14 +0200
Are you going through a break-up or divorce?
Do you need your Ex back fast? Dnot cry anymore, contact Dr .Goodluck for powerful Love spell that work fast now!! I was hurt and heart broken when my Husband breakup with me, and i could not know what next to do again, I love my Husband so much but he was cheating on me with another woman and this makes him break up with me so that he can be able to get marred to the other lady and this lady i think use witchcraft on my Husband to make him hate me and our kids and this was so critical and uncalled-for,I cry all day and night for God to send me a helper to get back my man until i went to Texas in USA to see a friend and who was having the same problem with me but she latter got her husband back and i asked her how she was able to get her husband back and she told me that their was a powerful spell caster called Dr .Goodluck that help with love spell in getting back lost lover back, and i decided to contact the same Dr .Goodluck and he told me what is needed to be done for me to have my man back and i did it although i doubted it but i did it and the Dr told me that i will get the result after 17hours, and he told me that my husband was going to call me and i still doubted his word, to my surprise my husband really called me and told me that he miss me so much, Oh My God! i was so excited, and today i am happy with my man again and we are joyfully living together as one big family and i thank the powerful spell caster Dr .Goodluck for bringing back my man and i decided to share my story on the internet that Dr .Goodluck is best spell caster online who i will always pray to live long to help his children in the time of trouble, If you have any problem contact Dr .Goodluck and i guarantee you that he will help you,Email him at: goodluck05spellcaster@gmail.com ,you can also call him or add him on whats-app: +2348138654465 or you can also contact him thrugh his website http://drgoodluck.simplesite.com
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Guest
2017-07-22 16:30:44 +0200
Hey guys, Effective powerful love spell to get your ex lover back now.
I'm so excited of getting my husband back after he left me and our 3 kids for another woman.
After 2 years of marriage, me and my husband has been into one quarrel or the other until he finally left me and moved to California to be with another woman. i felt my life was over and my kids thought they would never see their father again. i tried to be strong just for the kids but i could not control the pains that torments my heart, my heart was filled with sorrows and pains because i was really in love with my husband. Every day and night i think of him and always wish he would come back to me, I was really upset and i needed help, so i searched for help online and I came across a website that suggested that Prophet Efe can help get ex back fast. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a (Love spell) for me. 28 hours later, my husband really called me and told me that he miss me and the kids so much, So Amazing!! So that was how he came back that same day,with lots of love and joy,and he apologized for his mistake,and for the pain he caused me and the kids. Then from that day,our Marriage was now stronger than how it were before,All thanks to Prophet Efe. he is so powerful and i decided to share my story on the internet that Prophet Efe real and powerful spell caster who i will always pray to live long to help his children in the time of trouble, if you are here and you need your Ex back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now. Here’s his contact: Email him at: efepowerfultemple@gmail.com ,
you can also call him or add him on Whats-app: +2347081602438 , ,
Carol Gates , 34 years, Texas, USA
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Guest
2017-07-22 08:46:35 +0200
My ex-boyfriend is back after he left me for another girl.
I'm so excited my broken Marriage has been restored & my boyfriend is back after he left me for another girl.
I needed him back desperately because i loved him so much.
I became very worried and needed help. as i was browsing through the internet,
I came across a website that suggested that Dr.Unity can help get ex back fast and stop a divorce or breakup and so on , So I felt I should give him a try.
I contacted him and he told me what to do and i did it, then he did a (return Love spell) for me. 28 hours later,
my boyfriend came back to me crying and begging for my forgiveness.
Today I'm so happy and i am recommend this great spell caster to anyone that truly needs an urgent solution to his or her broken relationships and marriage. Simply contact the great "Dr.Unity"
If you have any problem contact him and i guarantee you that he will help you., email him at: Unityspelltemple@gmail.com ,
you can also call him or add him on Whats-app: +2348071622464 , you can also visit his website:http://unityspelltemple.webs.com .
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Guest
2017-07-21 23:42:08 +0200
Are you going through a break-up or divorce?
Do you need your Ex back fast? Dnot cry anymore, contact Dr .Goodluck for powerful Love spell that work fast now!! I was hurt and heart broken when my Husband breakup with me, and i could not know what next to do again, I love my Husband so much but he was cheating on me with another woman and this makes him break up with me so that he can be able to get marred to the other lady and this lady i think use witchcraft on my Husband to make him hate me and our kids and this was so critical and uncalled-for,I cry all day and night for God to send me a helper to get back my man until i went to Texas in USA to see a friend and who was having the same problem with me but she latter got her husband back and i asked her how she was able to get her husband back and she told me that their was a powerful spell caster called Dr .Goodluck that help with love spell in getting back lost lover back, and i decided to contact the same Dr .Goodluck and he told me what is needed to be done for me to have my man back and i did it although i doubted it but i did it and the Dr told me that i will get the result after 17hours, and he told me that my husband was going to call me and i still doubted his word, to my surprise my husband really called me and told me that he miss me so much, Oh My God! i was so excited, and today i am happy with my man again and we are joyfully living together as one big family and i thank the powerful spell caster Dr .Goodluck for bringing back my man and i decided to share my story on the internet that Dr .Goodluck is best spell caster online who i will always pray to live long to help his children in the time of trouble, If you have any problem contact Dr .Goodluck and i guarantee you that he will help you,Email him at: goodluck05spellcaster@gmail.com ,you can also call him or add him on whats-app: +2348138654465
http://goodluck05spellcaster.yolasite.com
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Guest
2017-05-14 06:09:40 +0200
Powerful love spells that works in 28 hours,get your Ex-lover back fast forever!!
“4 weeks ago my husband left me and our 3 kids for another woman and I want him back. I Love him with all my heart and I will do anything to get him back, i was so frustrated and i could not know what next again, I cry all day and night for God to send me a helper to get back my man. I became very worried and needed help. as i was browsing through the internet one day, I came across a website that suggested that Dr.Unity can help get ex back fast and stop a divorce or breakup and so on. So, I felt I should give him a try. I contacted him and told him my problems and he told me what to do and i did it and he did a (Lover spell) for me. 28 hours later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again. Dr.Unity is the best online spell caster that is powerful and genuine. If you have any problem contact him and i guarantee you that he will help you. Here’s his contact: Email him at: Unityspelltemple@gmail.com , you can also call him or add him on whats-app: +2348071622464 ,Website: http://unityspelltemple.yolasite.com
Caroline Tommy,UK.”
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Guest
2016-09-19 11:46:46 +0200
My Dear friends online, My name is Ashley Lisa And i live in USA, New York, I have to give this miraculous testimony, which is so unbelievable until now. I had a problem with my Ex husband 2 years ago, which lead to our break up. I was not myself again, i felt so empty inside me, my love and financial situation became worst, until a close friend of mine told me about a spell caster who helped her in the same problem too his name is Doctor Ogboni. I email the spell caster and i told him my problem and i did what he asked of me, to cut the long story short. Before i knew what was happen, less than two days my husband gave me a call and told me that he was coming back to me i was so happy to have him back to me. The most interesting part of the story is that am pregnant. Thanks to Doctor Ogboni for saving my marriage and for also saving others own too. Continue your good work, If you are interested to contact the great spell caster email address: ogbonispelltemple@hotmail.com or call him :+2347054263874
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Guest
2016-09-19 11:46:19 +0200
Hi, my husband and I have been together 17 years are married for 5, I recently had a one night stand with a man and I told my husband about it, he basically said ok we will get through this, a week later I found out that for months he has been talking to women on adult chat rooms, I’m upset about this and now we keep arguing over everything that’s happened. I suggested counseling but he won’t go, last night he said he can’t get passed this and wants a divorce, I love him very much and I want to stay with him, we have 2 children ages 7 and 5 and I know their hearts will break. We also own 2 businesses together and I don’t want things to get messy since i reach Dr. Mako on his email: Makospelltemple@yahoo.com all my marriage problems was solve im now the desirable woman i want to be thank you Dr. Mako you are God sent to save my marriage.his phone number: +2348108737816.
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Guest
2016-04-03 05:49:06 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High monicaspiritualtemple@gmail.com anytime, he might be the answer to your problems. Here's his contact: monicaspiritualtemple@gmail.com or call him +2348134493948
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