"This master regulator is normally turned off in adult cells, but it’s very active during embryonic development and in highly aggressive tumors" said Linda Resar, M.D., an associate professor of medicine, affiliate in the Institute for Cell Engineering at the Johns Hopkins University School of Medicine.
"Our work shows for the first time that switching this gene off in aggressive cancer cells dramatically changes their appearance and behavior."
Resar has been investigating genes in the master regulator's family, known as high mobility group or HMG genes for twenty years. On top of their role in cancer these genes are essential for giving stem cells their special powers and that's no coincidence
"Many investigators account cancer cells to be the evil twin of stem cells, because like stem cells, cancer cells must acquire special properties to enable the tuber to grow and metastasize or spread to different sites," she explained.
In an earlier study , Resar and her team devised techniques to block the HMGA1 gene in cells in order to study its role in those cells. In their researches, they discovered that HMGA1 is revelant for reprogramming adult cells, like blood or skin cells, into stem cells that share most, if not all, properties of embryonic stem cells.
In the newest reported study, the Resar team applied the same techniques to several strains of human breast cancer cells in the laboratory.
"The aggressive breast cancer cells grow rapidly and normally appear spindle-shaped or thin and elongated. Remarkably, within a few days of blocking HMGA1 expression, they appeared rounder and much more like normal breast cells growing in culture," said Resar.
Finally, Resar says, is trying to develop a therapy based on that principle. The group of researches is working with other researchers at Johns Hopkins to see whether HMGA1 could be delivered to tubers inside nanoparticles.
Another possible approach, she says, would be to block not HMGA1 itself, but one of the pathways or processes that it affects.
Source:
www.sciencedaily.com [http://www.sciencedaily.com/releases/2013/05/130502185252.html]
[accession date: May 2 2013]
Agnieszka Dąbrowska
Guest
2020-05-07 10:30:42 +0200
How I Got My Ex Husband Back...........
I am Shannon by name. Greetings to every one that is reading this testimony. I have been rejected by my husband after three(3) years of marriage just because another woman had a spell on him and he left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address Makospelltemple@yahoo.com , have help a woman to get back her husband and i gave him a reply to his address and he told me that a woman had a spell on my husband and he told me that he will help me and after 2 days that i will have my husband back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my husband. Thanks for Dr.Mako. His email: Makospelltemple@yahoo.com OR.His WhatsApp Number:+2347054263874.
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Guest
2020-03-16 21:44:31 +0100
I came across many testimonies on net testifying of Dr winner a voodoo spell caster that will help you cast a LOTTERY spell and give you the rightful numbers to win the lottery, I didn't believe it, at first but as life got badder i decided to take a try, now my try has made me a millionaire, i have been playing all types of lottery since 7 years now but i have not win up to $1000,after contacting him he cast the spell and give me the hot figures behold i won( FIFTY MILLIONS DOLLARS) now i am a living testimony of the good works of Dr winner A gifted man with a great powers, it is my secret but i decided to make the world known to it as it might be a help to any one who is interested, this happens last week ago you are free to contact him or via Email: Winnersspellcast@gmail.com or via his website:https://winnersspellcast.blogspot.com or his whatsapp +2348138289852
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Guest
2020-01-12 13:22:46 +0100
What a wonderful and a straight forward spell caster that has brought back joy and happiness into my life! Am giving this testimony because am so happy, I want to thank Dr. Iwisa for the great thing He has done in my life , He brought happiness back to my life, I never believed in spell casters until my life fell apart when my lover of 6 years decided to call it quit almost when we wanted to get married. I was so emotional breakdown to the extent i could not do anything reasonable again, after 2months in pain before an old friend of mine introduced me to a spell caster on line called Dr Iwisa, this was after I have been scammed by various fake spell casters. I was introduced me to Dr Iwisa a true Spell Caster. In less than 24 hours i saw wonders, my lover came back to me and my life got back just like a completed puzzle, and after 1month later we got married and it was just like a dream to me because i thought i had lost him forever. Thank you Dr. iwisa for helping me but most of all, Your Honesty and Fast Accurate Results. email: superiorspellhome@gmail.com WhatsApp +27730886631 Website: www.superiorspellhome.com
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Guest
2020-01-11 01:14:59 +0100
What a wonderful and a straight forward spell caster that has brought back joy and happiness into my life! Am giving this testimony because am so happy, I want to thank Dr. Iwisa for the great thing He has done in my life , He brought happiness back to my life, I never believed in spell casters until my life fell apart when my lover of 6 years decided to call it quit almost when we wanted to get married. I was so emotional breakdown to the extent i could not do anything reasonable again, after 2months in pain before an old friend of mine introduced me to a spell caster on line called Dr Iwisa, this was after I have been scammed by various fake spell casters. I was introduced me to Dr Iwisa a true Spell Caster. In less than 24 hours i saw wonders, my lover came back to me and my life got back just like a completed puzzle, and after 1month later we got married and it was just like a dream to me because i thought i had lost him forever. Thank you Dr. iwisa for helping me but most of all, Your Honesty and Fast Accurate Results. email: superiorspellhome@gmail.com WhatsApp +27730886631 Website: www.superiorspellhome.com
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Guest
2020-01-11 01:14:59 +0100
What a wonderful and a straight forward spell caster that has brought back joy and happiness into my life! Am giving this testimony because am so happy, I want to thank Dr. Iwisa for the great thing He has done in my life , He brought happiness back to my life, I never believed in spell casters until my life fell apart when my lover of 6 years decided to call it quit almost when we wanted to get married. I was so emotional breakdown to the extent i could not do anything reasonable again, after 2months in pain before an old friend of mine introduced me to a spell caster on line called Dr Iwisa, this was after I have been scammed by various fake spell casters. I was introduced me to Dr Iwisa a true Spell Caster. In less than 24 hours i saw wonders, my lover came back to me and my life got back just like a completed puzzle, and after 1month later we got married and it was just like a dream to me because i thought i had lost him forever. Thank you Dr. iwisa for helping me but most of all, Your Honesty and Fast Accurate Results. email: superiorspellhome@gmail.com WhatsApp +27730886631 Website: www.superiorspellhome.com
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Guest
2019-09-26 17:47:03 +0200
HOW I GOT MY EX HUSBAND BACK WITH THE HELP OF REAL AND EFFECTIVE SPELL FROM DR Osasu My name is Olivia Jayden, I never thought I will smile again, My husband left me with two kids for one year, All effort to bring him back failed I thought I'm not going to see him again not until I met a lady called Jesse who told me about a spell caster called Dr. Osasu , She gave me his email address and mobile number and I contacted him and he assured me that within 48hours my husband will come back to me, In less than 48hours my husband came back started begging for forgiveness saying it is the devils work, so I'm still surprise till now about this miracle,i couldn't conceive but as soon as the spell was cast,i became pregnant and gave birth to my third child,if you need any assistance from him you can contact him via:email: drosasu25@gmail.com Or WhatsApp or call him now:
Website http://Drosasu.com.ng +2347064365391 . Dr.Osasu also cures: 1. HIV / AIDS 2. HERPES 1/2 3. CANCER 4. ALS (Lou Gehrig’s disease) 5. Hepatitis B
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Guest
2018-10-08 16:41:22 +0200
After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: spiritualherbalisthealing@gmail.com or call him +2348164728160 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS
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Guest
2017-07-22 08:46:28 +0200
My ex-boyfriend is back after he left me for another girl.
I'm so excited my broken Marriage has been restored & my boyfriend is back after he left me for another girl.
I needed him back desperately because i loved him so much.
I became very worried and needed help. as i was browsing through the internet,
I came across a website that suggested that Dr.Unity can help get ex back fast and stop a divorce or breakup and so on , So I felt I should give him a try.
I contacted him and he told me what to do and i did it, then he did a (return Love spell) for me. 28 hours later,
my boyfriend came back to me crying and begging for my forgiveness.
Today I'm so happy and i am recommend this great spell caster to anyone that truly needs an urgent solution to his or her broken relationships and marriage. Simply contact the great "Dr.Unity"
If you have any problem contact him and i guarantee you that he will help you., email him at: Unityspelltemple@gmail.com ,
you can also call him or add him on Whats-app: +2348071622464 , you can also visit his website:http://unityspelltemple.webs.com .
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Guest
2017-07-21 23:42:14 +0200
Are you going through a break-up or divorce?
Do you need your Ex back fast? Dnot cry anymore, contact Dr .Goodluck for powerful Love spell that work fast now!! I was hurt and heart broken when my Husband breakup with me, and i could not know what next to do again, I love my Husband so much but he was cheating on me with another woman and this makes him break up with me so that he can be able to get marred to the other lady and this lady i think use witchcraft on my Husband to make him hate me and our kids and this was so critical and uncalled-for,I cry all day and night for God to send me a helper to get back my man until i went to Texas in USA to see a friend and who was having the same problem with me but she latter got her husband back and i asked her how she was able to get her husband back and she told me that their was a powerful spell caster called Dr .Goodluck that help with love spell in getting back lost lover back, and i decided to contact the same Dr .Goodluck and he told me what is needed to be done for me to have my man back and i did it although i doubted it but i did it and the Dr told me that i will get the result after 17hours, and he told me that my husband was going to call me and i still doubted his word, to my surprise my husband really called me and told me that he miss me so much, Oh My God! i was so excited, and today i am happy with my man again and we are joyfully living together as one big family and i thank the powerful spell caster Dr .Goodluck for bringing back my man and i decided to share my story on the internet that Dr .Goodluck is best spell caster online who i will always pray to live long to help his children in the time of trouble, If you have any problem contact Dr .Goodluck and i guarantee you that he will help you,Email him at: goodluck05spellcaster@gmail.com ,you can also call him or add him on whats-app: +2348138654465
http://goodluck05spellcaster.yolasite.com
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Guest
2017-05-14 06:09:33 +0200
Powerful love spells that works in 28 hours,get your Ex-lover back fast forever!!
“4 weeks ago my husband left me and our 3 kids for another woman and I want him back. I Love him with all my heart and I will do anything to get him back, i was so frustrated and i could not know what next again, I cry all day and night for God to send me a helper to get back my man. I became very worried and needed help. as i was browsing through the internet one day, I came across a website that suggested that Dr.Unity can help get ex back fast and stop a divorce or breakup and so on. So, I felt I should give him a try. I contacted him and told him my problems and he told me what to do and i did it and he did a (Lover spell) for me. 28 hours later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again. Dr.Unity is the best online spell caster that is powerful and genuine. If you have any problem contact him and i guarantee you that he will help you. Here’s his contact: Email him at: Unityspelltemple@gmail.com , you can also call him or add him on whats-app: +2348071622464 ,Website: http://unityspelltemple.yolasite.com
Caroline Tommy,UK.”
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Guest
2016-09-19 11:46:52 +0200
My Dear friends online, My name is Ashley Lisa And i live in USA, New York, I have to give this miraculous testimony, which is so unbelievable until now. I had a problem with my Ex husband 2 years ago, which lead to our break up. I was not myself again, i felt so empty inside me, my love and financial situation became worst, until a close friend of mine told me about a spell caster who helped her in the same problem too his name is Doctor Ogboni. I email the spell caster and i told him my problem and i did what he asked of me, to cut the long story short. Before i knew what was happen, less than two days my husband gave me a call and told me that he was coming back to me i was so happy to have him back to me. The most interesting part of the story is that am pregnant. Thanks to Doctor Ogboni for saving my marriage and for also saving others own too. Continue your good work, If you are interested to contact the great spell caster email address: ogbonispelltemple@hotmail.com or call him :+2347054263874
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Guest
2016-09-19 11:46:35 +0200
How I Got My Ex Husband Back...........
I am Shannon by name. Greetings to every one that is reading this testimony. I have been rejected by my husband after three(3) years of marriage just because another woman had a spell on him and he left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address Makospelltemple@yahoo.com , have help a woman to get back her husband and i gave him a reply to his address and he told me that a woman had a spell on my husband and he told me that he will help me and after 2 days that i will have my husband back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my husband. Thanks for Dr.Mako. His email: Makospelltemple@yahoo.com OR. his phone number: +2348108737816.
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