- Central European Biotechnology Portal
be visible on the BioBusiness market                  ISSN 2300-0228
East London genomic study of Asians will shed light on new drugs design

East London genomic study of Asians will shed light on new drugs design

Publish date: 2015-04-02

East London Genes and Health project, assuming sequencing genomes of 100 000 Pakistanis and Bangladeshis, has been launched on March 12, 2015. Comparing to people of European ancestry, these ethnic groups more often suffer from various illnesses, mainly heart diseases and type II diabetes. The project aims to analyze a genetic background and to select specific genes essential in disease outcome. The latters can possibly serve as a groundwork for new drugs design.

Tags: mutations , genome sequencing , East London Genes and Health

Hidden in genes

Immigrants from South Asia are abundant ethnic groups in east London, which in comparison to native British characterize in 2-fold and 5-fold higher morbidity to heart diseases and type II diabetes, respectively. Asians also often reveal weaker response to routinely used medicines.













However, in Pakistani and Bangladeshi population some unusually healthy individuals can be found. One of reasons of such good health can be a phenomenon of “human knock-out”. Knock-outs reflect a situation, when both alleles of a particular gene, each from one parent, are nonfunctional. It allows to demonstrate a phenotype dependent on a single gene.

In nature, knock-outs are extremely rare, however the probability is higher in children of related parents. Marriages between cousins or relatives and giving birth to children are frequent in ethnic minorities of Asians in Europe. 10 % of Bangladeshis and 30-40 % of Pakistanis have related parents.

Researchers from Queen Mary University in London are hoping to identify at least some of genes, which improve health when knocked-out. Such correlation could be the basis for new drugs, which will trigger the same positive outcome as inactivated genes. Similar example of PCSK9 gene has been identified in the genome of “perfectly healthy” woman in Texas, in which both mutated alleles has led to unusual decrease in cholesterol level. The same gene in a functional form is found among a group of French families with very high cholesterol levels. This particular gene identification has led to creation of a new class of medicines.


The project is planned for 4 years. It will engage 100 000 adults of Pakistani and Bangladeshi origin, age 16 and older, including healthy and unhealthy individuals. Volunteers will be asked to donate saliva (spit) and authorize researches to have insight into their medical records. Exon regions of Asian’s DNA will be sequenced in Wellcome Trust’s Sanger Institute by the end of 2017. Genomic data will be analyzed in The Broad Institute in Cambridge, Massachusetts. Data will be analyzed in a context of medical records, particularly heart diseases and diabetes. The project, funded by Wellcome Trust and UK Medical Research Council, will consume ₤4 million.

Researchers hope to select specific knock-outs, as well as analyze general genetic make-up of Asians in UK, since this ethnic group was markedly under-represented in medical research. Obtained results will be valuable not only for a local community, but also in a global aspect.




Add comment
2016-04-03 04:23:08 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High anytime, he might be the answer to your problems. Here's his contact: or call him +2348134493948
2016-04-03 02:42:22 +0200
'After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: or call him +2349055637784 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS'
2015-04-27 21:56:37 +0200
How to get lost love back even if you made some mistakes Am here to testify what this great spell caster done for me. i never believe in spell casting, until when i was was tempted to try it. i and my husband have been having a lot of problem living together, he will always not make me happy because he have fallen in love with another lady outside our relationship, i tried my best to make sure that my husband leave this woman but the more i talk to him the more he makes me fell sad, so my marriage is now leading to divorce because he no longer gives me attention. so with all this pain and agony, i decided to contact this spell caster to see if things can work out between me and my husband again. this spell caster who was a woman told me that my husband is really under a great spell that he have been charm by some magic, so she told me that she was going to make all things normal back. she did the spell on my husband and after 5 days my husband changed completely he even apologize with the way he treated me that he was not him self, i really thank this woman her name is Dr Aluta she have bring back my husband back to me i want you all to contact her who are having any problem related to marriage issue and relationship problem she will solve it for you. her email is she is a woman and she is great. wish you good time. He cast spells for different purposes like (1) If you want your ex back. (2) if you always have bad dream (3) You want to be promoted in your office. (4) You want women/men to run after you. (5) If you want a child. (6) You want to be rich. (7) You want to tie your husband/wife to be yours forever. (8) If you need financial assistance. (9) HIV/AIDS CURE (10) is the only answer to that your problem of winning the lottery Contact him today on: