CEbiotech.com - Central European Biotechnology Portal
be visible on the BioBusiness market                  ISSN 2300-0228
How cancer cells can interact with each other?

How cancer cells can interact with each other?

Publish date: 2015-01-28

Interactions between cells are of crucial importance for the proper functioning of tissues and the whole multicellular organisms. During pathological processes, such as cancer progression, alterations in cell-cell adhesion are very common. The molecular events underlying these changes must be deeply investigated in order to develop efficient anti-cancer therapies.

Tags: junction , Jonas Fuxe , epithelium , interaction , cancer

A proper organization of tissues is dependent on direct interactions of cells with each other or with extracellular matrix. Transient connections are formed e.g. during inflammation between cells of immune system whereas stable ones are indispensable for tissue integrity, for instance, correct structure of epithelial sheets. When intercellular adhesion is disrupted, the cells may become “invasive”. Such a process is reported to be involved in development and progression of cancer.

The interaction between cells is possible thanks to various types of integral membrane proteins ,cell-adhesion molecule (CAMs), such as cadherins, selectins or integrins. The clusters of CAPs form so called junctions, which can be classified as tight junction, gap junction, cell-cell and cell-matrix junctions.

Tight junctions are responsible for connections of plasma membranes of neighboring cells in a sheet, therefore, preventing small molecule leakage into the extracellular space. In contrast, gap junctions connecting cytoplasm of adjacent cells enable molecules and ions to diffuse between cells as they serve as open channels. Hence, gap junctions play important roles in metabolic activities and electric communication.

As the epithelium is a tissue most commonly affected by cancer, it is intensively investigated inter alia in terms of cell-cell adhesion abnormalities. Epithelial cells are organized in adjoining sheets comprising of polarized cells limited by basement membrane, which separates them from the stroma. Disorganization of the epithelium interaction with stroma may trigger the process of carcinogenesis. Due to the loss of cellular adhesion, cells can enter the blood or lymphatic circulatory system and metastasize. There are numerous reports suggesting that CAMs might be associated with invasive process in different human cancers. Dr Jonas Fuxe, associate professor at the Department of MBB in Karolinska Institute emphasizes the importance of cell-cell communication among cancer cells.

Further studies unveiling mechanisms of  cell-cell interactions in normal and pathological states are necessary in order to provide novel diagnostic strategies as well as efficient therapies directed against particular type of cancer.

Sources:

http://www.ncbi.nlm.nih.gov/books/NBK21599/

http://www.ncbi.nlm.nih.gov/pubmed/15218541

http://www.mhhe.com/biosci/genbio/raven6b/graphics/raven06b/other/raven06b_07.pdf

Maciej Smolarz

Comments:

Add comment
Joy
2018-05-10 08:35:30 +0200
Greetings to the general public,i want to inform the public how i was cured of firbrod by blackspellfactory .i visited different hospital but they gave me list of drugs which is very expensive to buy and never cured me, I was browsing through the Internet searching for remedy and i saw comment of people talking about how blackspellfactory cured them. when i contacted him he gave me hope and told me not to worry that all is well, before the firbrod I was unable to get pregnant I told him all I was going through and he wrote saying o yea women of little faith I was shocked he said i will cast a spell on you 1 week is too much to confirm you are cured and get pregnant, 6days later it seriously worked for me, am a free person now I went for check up the doc said wow impossible no firbrod and and a week pregnant I burst into tears.sir God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him on email: blackspellfactory@outlook thanks.
Gregorykushi
2018-02-24 19:38:27 +0100
Buy Palbace Lemon Quaaludes,BOTOX,XANAX,VA, We have medications for the treatment of chronic back pains, cough, anxiety,panic disorder, depression, erectile dysfunction, dysfunction,adhd,narcolepsy, obesity,depression, fatigue,Weight Loss supplement and more online (no prescription required).We sell quality medications online at affordable and discount prices. Fast and secure overnight delivery. We are ready to sell minimum quantities and large supplies of our product worldwide (SHIPPING IS WORLDWIDE). Below is a list of some of our product : Klonopin 1mg,2mg Ativan Opama 10mg,20mg,30mg,40mg Ambien Soma 350mg Oxycotin Hydrocodone Roxicodone Percocert Lorazepam 2.5 mg (Ativan) Clonazepam 2 mg (Rivotril) Valium 2mg,5mg and 10mg Fentalyn patches Tramadol (Ultram) 50mg etc........ We offer: - Good quality Medications - Good and affordable prices. - Fast and Reliable delivery -Tracking Available! -Tracking numbers available with references. - Various shipping option (Overnight and Airmail). -Shipping secure and discreet ,Delivery time OVERNIGHT & 1-5 days depending on location. - Buy with and without Prescription Required! -Additional Discounts on Bulk Orders - Buy Direct and Save Time and Money! - 100% Customer Satisfaction Guaranteed ! Contact via details below: EMAIL.....jamesbernal2001@gmail.com CONTACT NUMBER...9046868791
Guest
2016-09-19 11:42:02 +0200
My Dear friends online, My name is Ashley Lisa And i live in USA, New York, I have to give this miraculous testimony, which is so unbelievable until now. I had a problem with my Ex husband 2 years ago, which lead to our break up. I was not myself again, i felt so empty inside me, my love and financial situation became worst, until a close friend of mine told me about a spell caster who helped her in the same problem too his name is Doctor Ogboni. I email the spell caster and i told him my problem and i did what he asked of me, to cut the long story short. Before i knew what was happen, less than two days my husband gave me a call and told me that he was coming back to me i was so happy to have him back to me. The most interesting part of the story is that am pregnant. Thanks to Doctor Ogboni for saving my marriage and for also saving others own too. Continue your good work, If you are interested to contact the great spell caster email address: ogbonispelltemple@hotmail.com or call him :+2347054263874
Guest
2016-09-19 11:41:33 +0200
How I Got My Ex Husband Back........... I am Shannon by name. Greetings to every one that is reading this testimony. I have been rejected by my husband after three(3) years of marriage just because another woman had a spell on him and he left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address Makospelltemple@yahoo.com , have help a woman to get back her husband and i gave him a reply to his address and he told me that a woman had a spell on my husband and he told me that he will help me and after 2 days that i will have my husband back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my husband. Thanks for Dr.Mako. His email: Makospelltemple@yahoo.com OR. his phone number: +2348108737816.
Guest
2016-04-03 04:31:36 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High monicaspiritualtemple@gmail.com anytime, he might be the answer to your problems. Here's his contact: monicaspiritualtemple@gmail.com or call him +2348134493948
Guest
2016-04-03 03:02:42 +0200
'After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: spiritualherbalisthealing@gmail.com or call him +2349055637784 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS'
See also
Researchers at Johns Hopkins University have identified a gene which repressed in tumor cells, puts a halt to c... Read more
Tags: medicine , cancer
Cancer experts from Denmark have found an enzyme that seems to induce cancer senescence.... Read more
Tags: cancer , medicine
On 1 November 2013, Genentech announced that the U.S. Food and Drug Administration (FDA) approved Gazyva (obinu... Read more
Tags: cancer , leukemia , CLL , antibody , Genentech , Roche , chemoterapy