- Central European Biotechnology Portal
be visible on the BioBusiness market                  ISSN 2300-0228

How to save even 3000 people a day? The development of the new antimalarial drug!

Publish date: 2013-03-20

With over 3.3 billion people living in areas at risk of malaria transmission and over 3000 of them dying every day, malaria is one of the most deadly disease worldwide. Even though this mosquito-borne disease is known to strike for over 10 000 years no really efficient and safe treatment has been developed during this period. Will promising new antimalarial drug developed by researchers from University of South Florida cease the disease?

Tags: malaria , drug , africa

Malaria is a serious disease caused by a parasite known as protest that commonly infects a

Malaria is a mosqito-borne disease

certain type of mosquito which feeds on humans. Symptoms of malaria are typically very sick with high fevers, shaking chills, and flu-like illness and untreated may be fatal. The USF researchers (part of larger Medicines for Malaria Venture (MMV) project) discovered and developed a number of potent substances to combat malaria known as quinolones. Quinolones (not to be confused with quinine - the predominant malarial medication until the 1920s), especially ELQ-300, which is undergoing the clinical testing, demonstrated impressive preventive and transmission-blocking combined with low possibility to develop resistant strains of malaria parasites. Moreover, it is believed to be produced cheaper than other existing antimalarial drugs, which is of great values as malaria strikes most often in poor developing countries. In addition, the new design makes ELQ-300 more effective at lower doses meaning smaller and potentially cheaper pills.

Map of malaria-endemic countries



Malaria parasites life cycle

The key factor for development of any antimalarial drug is fine-tuning a drug to obtain a  long half-life to prevent malaria in host as well as to protect  against reinfection for long time. It is all due to mode of infection of malaria. Humans are affected by the malaria parasite after it enters the body through the bite of an infected mosquito. The infecting parasites target for liver and for most types of malaria multiply and destroy liver cells, going back to blood system. The parasites are then modified to attack red blood cells, rapidly create more parasites spreading through the whole body.

In the case of ELQ-300 the potential lies in its ability to kill malaria parasites at all three stages of its life cycle not only curing sick people, but also preventing the infections as it works in mosquitoes’ bodies as well.  It differs from available alternative treatments as it does not generate drug-resistant strains of the malaria parasite like atovaquone, even though it targets the same biological pathway.


Will ELQ-300 fulfil all expectations put in it and cease the malaria for good? Will it be as cheap as the researchers want it to be? For the sake for the poorest we have to hope so!

Jacek Plewka



Add comment
2018-10-08 16:14:20 +0200
After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: or call him +2348164728160 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS
2016-04-03 05:57:57 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High anytime, he might be the answer to your problems. Here's his contact: or call him +2348134493948
See also
A French multinational company Pierre Fabre Pharmaceuticals has announced a start of Phase IIa clinical trials ... Read more
Tags: Pierre Fabre , clinical trials , drug , schizophrenia , F17464
Clinical trials are one of the indispensable steps of drug development. They are especially crucial for the ass... Read more
Tags: CEE , clinical trials , pharmaceutical , company , drug
Novartis drug “Jakavi” has been approved by the European Commission for the therapy of rare blood cancer, polyc... Read more
Tags: Novartis , drug , targeted therapy , approval , eu , cancer