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Immatics and Roche sign cancer vaccine and immunotherapy collaboration

Immatics and Roche sign cancer vaccine and immunotherapy collaboration

Publish date: 2013-11-18

Collaboration spans the discovery, development and commercialization of cancer vaccines and other cancer immunotherapies in gastric, lung and prostate cancer

Tags: cancer , Roche , Immatics , collaboration , partnership

Immatics biotechnologies GmbH and Roche (SIX: RO, ROG; OTCQX: RHHBY) announced a strategic research and development collaboration covering multiple cancer vaccines and immunotherapeutics.

The agreement will focus on the research, clinical development and commercialisation of a number of new tumour-associated peptide (TUMAP)-based cancer vaccine candidates and other immunotherapies in oncology, targeting primarily gastric, prostate and non-small cell lung cancer. The most advanced cancer vaccine candidate covered by the agreement is IMA942, for the treatment of gastric cancer, which is ready for phase I trials. Roche will be responsible for the clinical development and commercialisation of all of the immunotherapies generated by immatics as a result of this collaboration.

In parallel with the clinical development of IMA942 by Roche, immatics will conduct research on behalf of Roche using its unique XPRESIDENT® technology platform to identify novel and relevant TUMAP candidates for the development of cancer vaccines and other compounds targeting cancer peptide antigens, primarily in gastric, prostate and non-small cell lung cancer. The XPRESIDENT® discovery platform is to date the only known high-throughput research technology to directly identify, quantify, and prioritize cancer antigens recognized by T lymphocytes (type of white blood cell) based on the ability of the immune system to detect them.

Under the terms of the agreement, immatics will receive an upfront payment of $17 million and committed research funding plus potential milestone payments that could reach values in excess of $1 billion and royalties across three cancer indications, based on sales of the cancer vaccines and immunotherapies resulting from this agreement.

“Roche is proud to initiate this partnership with immatics, which is widely recognized as a leader in the field of tumour antigen identification and novel cancer vaccine development. The wealth of relevant cancer-specific antigens that we expect to emerge from this research collaboration will provide an extraordinary opportunity to elicit broad tumour-specific immune responses upon vaccination, especially when combined with other immunomodulatory molecules in our pipeline. Discovery of novel antigens also will provide unique targets for other protein-based anti-cancer agents currently under development,” commented Hy Levitsky, Head of Cancer Immunology Experimental Medicine at Roche.

Paul Higham, CEO of immatics, said: “We are delighted that Roche through this alliance has recognized the huge potential of our TUMAP-based approach to rapidly develop cancer vaccines that we believe hold great promise for cancer patients in terms of overall survival improvement and quality of life benefits across a broad range of cancers. It also validates the potential for XPRESIDENT® identified TUMAPs to play a key role in the development of other cancer immunotherapies. We are looking forward to working with Roche to make a significant difference to the outcome for patients with gastric, prostate and lung cancer.”

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2018-10-10 07:59:20 +0200
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2017-07-22 08:45:27 +0200
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2017-05-18 21:22:43 +0200
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2017-05-14 06:09:19 +0200
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2016-04-03 05:35:13 +0200
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2016-04-03 03:52:41 +0200
'After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: spiritualherbalisthealing@gmail.com or call him +2349055637784 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS'
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