CEbiotech.com - Central European Biotechnology Portal
be visible on the BioBusiness market                  ISSN 2300-0228
Movember – about a microbiome in (prostate) cancer risk

Movember – about a microbiome in (prostate) cancer risk

Publish date: 2015-11-16

10 years ago a Nobel Prize awarded a discovery connecting Helycobacter pylori with gastric carcinogenesis. But only today, a host-microbiome relation research starts to enter its critical phase. It turns out, that we are not the only architects of our own fortune – they are, small frequenters of our guts. In November, we focus especially on prostate cancer issue.

Tags: cancer , movember , prostate cancer , microbiome , microflora , cancer risk , holobiont

A phenomenon called a “paradox of cancer immunotherapy” concerns a bilateral role of regulatory T cell (Treg). It is included in a complex microenvironment surrounding neoplastic changes, which promotes cancer development via ongoing pro-inflammatory events. Treg cells of FOXP3+ CD4+ CD25+/high phenotype are sheriffs of our immunologic homeostasis. However, plenty of literature data describe their opposite role – in neoplastic environment Tregs often don’t serve as suppressor cells, but rather promote cancer development and defend natural anticancer immunologic response, external immunotherapy and vaccines. As a result, Treg cells became a target in several types of cancer immunotherapy.

In melanoma, a blockage of CTLA-4 antigen on cytotoxic T cells is employed, which leads to depletion of cancer-associated Treg cells. However, as was shown in latest research, a positive response is dependent on a presence of Bacteroides bacteria. In both mice and patients, T cells specifically stimulated by B. thetaiotaomicron and B. fragilis were more effectively blocked by anti-CTLA antibodies. What is more, mice deprived of gut microflora didn’t response to therapy. After fecal transplant, a vaccination with B. fragilis polysaccharide antigen or transplantation of already stimulated T cells – the ability to effectively block CTLA-4 in sick mice has been restored.

Those data confirms an immunostimulating role of gut microflora, which is of importance not only in cancer defense, but also in autoimmune diseases. A cross-talk between human microbiome and functioning of Treg cells and general immune response is presented on a picture below:


Ref. Poutahidis T et al. 2014

Above data help to understand an influence of microflora on neoplasia events distant from digestive track. Human organism becomes to be perceived as a “holobiont”, thus a body with a whole symbiotic microbiome it harbors. In a context of carcinogenesis, it is important to tell a microbiome composition and metabolic fluctuations which results from neoplastic changes from those which are a causable factor of cancer formation. This field of research is still a very young branch of science, which is scarcely enteric its critical phase. In August, a huge statistical report was published, showing an influence of recurrent antibiotic exposure on formation of 15 types of cancer. For example, a repetitive administration of penicillins increases a risk of esophageal, gastric, pancreatic and lung cancer.

“Movember”

Composition and fluctuation of bacterial flora are also important in prostate cancer formation. Escherichia coli, Pseudomonas aeruginosa and Enterococci are a frequent cause of urinary track infections, which can lead to a chronic prostatitis and overall increase in pro-inflammatory cytokines level. In recently published report, patients with prostate cancer and benign prostatic hyperplasia (BPH) were examined for microflora present in expressed prostatic secretions, sperm and urine. As compared do BPH group, patients with cancer revealed elevated number of Bacteroidetes bacteria, Alphaproteobacteria, Firmicutes bacteria, Lachnospiraceae, Propionicimonas, Sphingomonas, and Ochrobactrum, and a decrease in Eubacterium and Defluviicoccus genus. As regards past antibiotic therapies, a prostate cancer risk increases moderately after recurrent administration of penicillins, quinolones, sulphonamides and tetracyclines.

Discoveries of latest years draw our attention to a huge role of host-microbiome interactions and shed new light on a “hygiene theory” – according to which, speaking colloquially, a frequent body washing is not that healthy. The awareness of a huge importance of microflora for a public health, raise an issue of a proper nutrition. What we eat is not only the subject of what we assimilate, but also - how it affects our microbiome. Latest research shown that a risk of cancer and obesity in mice is dependent not only on a family history and diet, but also on gut microflora heritage, passing from mother to offspring, up to a second generation. A question is: will a “microbiome engineering” and designing a whole microcommunities in health care be only a matter of time…?

Monika Kossakowska-Zwierucho

 

Sources:

  • Poutahidis T et al. Gut microbiota and the paradox of cancer immunotherapy. Front Immunol. 2014 Apr 7;5:157
  • Vétizou M et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015 Nov 5
  • Haining Yu et al. Urinary microbiota in patients with prostate cancer and benign prostatic hyperplasia. Arch Med Sci. 2015 Apr 25; 11(2): 385–394
  • Boursi B et al. Recurrent antibiotic exposure may promote cancer formation - Another step in understanding the role of the human microbiota? Eur J Cancer. 2015 Aug 31
  • Poutahidis T et al. Dietary microbes modulate transgenerational cancer risk. Cancer Res. 2015 Apr 1;75(7):1197-204
  • picture: http://teabba.com.au/get-involved-now-for-movember-2014/

Comments:

Add comment
Guest
2018-06-08 02:41:14 +0200
I'm so excited. I cant believe it! LORD JUMA your love spell casting really worked! My ex-husband is back after he left me and the kids, he sent me an SMS last night, wanting us to get back together again...and here we are! Yes, I’m extremely happy that we are living together again. My name is TRIANA ANDERSON from CANADA, My husband and I have been married for about 6yrs now. We were happily married with two kids, a boy and a girl. 3 months ago, I started to notice some strange behavior from him and a few weeks later I found out that my husband is seeing someone else. He started coming home late from work, he hardly care about me or the kids anymore, Sometimes he goes out and doesn't even come back home for about 2-3 days. I did all I could to rectify this problem but all to no avail. I became very worried and needed help. As I was browsing through the internet one day, I came across a website that suggested LORD JUMA can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and told him my problems and he told me what to do and i did it and he did a spell for me. 28 hours later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again. LORD JUMA is the best online spell caster that is powerful and genuine. If you have any problem contact him and i guarantee you that he will help you. Here’s his contact: Email him at: mercyfullsolutionhome@yahoo.com or mercyfullsolutionhome@gmail.com add him up on whatsApp @ +1 (859)-203-2241 Via is website:: http://mercyfullsolutionhome.website2.me/ his blog page https://mercyfullsolutionhome.blogspot.com or https://trianasson.blogspot.com
Guest
2018-02-23 13:08:11 +0100
URGENT LOVE-SPELL TO GET YOUR EX BOYFRIEND/GIRLFRIEND BACK FAST My girlfriend and I were happy as far I could tell and I never thought that we would break up. When her cousin died in a tragic car accident she went to her family in Mexico for a week. I couldnt go because I was in the middle of entertaining out of town clients for work. She did not seem to be upset that I could not go so I let her be. The next thing I knew, she reconnected with an old friend from high school that she had a crush on years back and they started to have an affair! I had no clue what was going on until she came back from Mexico. She proceeded to see this old friend and I caught her and her old friend one night hugging each other. I confronted her and she told me the truth about what happened. We broke up and went our separate ways. Neither of us fought for our relationship. I was angry and decided not to be upset about it and just keep it moving. Then after about few months of no contact with her I became sad. I wanted her to tell me she wanted to be with me and not her old friend. I contacted Dr.Ewan for a love spell and he truly helped me! he was able to get her to miss me she wanted us to get back together again. She had lot of regrets and felt bad for not fighting to keep me and for cheating in generally. she cherish our relationship so much more now and we are together now! You can also get your lover back with the help of Dr.Ewan contact him through his mobile number +2349078040531 or add him on whatsapp on +2349057353987 or check out his webpage http://allwomenstalk.com/p/58034af4f725a97d108b4569. contact him today on covenantsolutiontemple@gmail.com now.
Guest
2018-02-23 12:41:04 +0100
URGENT LOVE-SPELL TO GET YOUR EX BOYFRIEND/GIRLFRIEND BACK FAST My girlfriend and I were happy as far I could tell and I never thought that we would break up. When her cousin died in a tragic car accident she went to her family in Mexico for a week. I couldnt go because I was in the middle of entertaining out of town clients for work. She did not seem to be upset that I could not go so I let her be. The next thing I knew, she reconnected with an old friend from high school that she had a crush on years back and they started to have an affair! I had no clue what was going on until she came back from Mexico. She proceeded to see this old friend and I caught her and her old friend one night hugging each other. I confronted her and she told me the truth about what happened. We broke up and went our separate ways. Neither of us fought for our relationship. I was angry and decided not to be upset about it and just keep it moving. Then after about few months of no contact with her I became sad. I wanted her to tell me she wanted to be with me and not her old friend. I contacted Dr.Ewan for a love spell and he truly helped me! he was able to get her to miss me she wanted us to get back together again. She had lot of regrets and felt bad for not fighting to keep me and for cheating in generally. she cherish our relationship so much more now and we are together now! You can also get your lover back with the help of Dr.Ewan contact him through his mobile number +2349078040531 or add him on whatsapp on +2349057353987 or check out his webpage http://allwomenstalk.com/p/58034af4f725a97d108b4569. contact him today on covenantsolutiontemple@gmail.com now.
Guest
2018-02-23 11:15:49 +0100
MY name is kapil weafer, I feel very happy to share my great and wonderful testimony with everyone on this site..: I was married for 4 years to my husband and all of a sudden another woman came into the picture he started hating me and he was abusive. but i still loved him with all my heart and wanted him at all cost.... He filed for divorce and my whole life was turning apart and i didn't know what to do, he moved out of the house and abandoned me and the kids... my very close friend told me about trying spiritual means to get my husband back and introduced me to a spell caster so i decided to try it. although i didn't believe in all those things then when he did the special prayers and spell, after 2 days, my husband came back and was pleading that he had realized his mistakes I just couldn't believe it, anyway we are back together now and we are happy in case anyone needs help here is his email address; driraborspellcaster@gmail.com His spells is for a better life OR call his number +13019098775
Guest
2018-01-26 11:45:00 +0100
I read testimonies about a love spell caster by Dr. Ereke on how he has helped lots of people in bringing back their ex lovers within 48hours, Sincerely I was just thinking if that was real and if this man could really help bring back my lover whom I love so much. I decided to contact him because I love my girlfriend very much and we have been apart for a couple of months I really missed her so much, I have tried all other means to get her back but couldn’t. I contacted erekespellcaster@yahoo. com and He told me that my ex will come back to me in the next 48 hours, Dr. Ereke released her up to know how much i loved and wanted her. And opened her eyes to picture how much we have share together. My ex is now back to me again. As I`m writing this testimony right now I`m the most happiest guy on earth and me and my girlfriend are living a happy life and our love is now stronger than how it was even before our break up. All thanks goes to Dr. Ereke for the excessive work that he has done for me by helping me to get back with my ex girlfriend. I would like to drop Dr. Ereke email address and hope you see this testimony and contact him if you have any problem Email him: erekespellcaster@yahoo. com
Guest
2017-09-06 15:00:15 +0200
So far so good i give thanks to Dr.Ogudugu for great work he did for me during my time of distress, And i have never seen anything that works so fast and so effective like the spell that Dr.Ogudugu cast on my lover which brought my lover back to me. Here is Dr.Ogudugu details: greatogudugu@gmail.com or WhatsApp No: +2348139793075 for further inquiry and assistance.
Guest
2017-07-26 19:14:15 +0200
Now you can get ex-Lover back and stop a divorce or break-up…Even If Your Situation Seems Hopeless.! My husband said he no longer loved me at the end of May this year and i was hurt and heart broken i felt like my life was about to end and I almost committed suicide, I was emotionally down for a very long time. Thanks to a spell caster called Dr.Unity, which I meet online, on one faithful day, as I was browsing through the internet and I came across a lot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb, cure cancer and other sickness, some testified that he can cast a spell to stop divorce and so on. I also come across one particular testimony and it was about a woman called Tracey Hilton, she testified about how he brought back her Ex lover in less than 28 hours and at the end of her testimony she dropped Dr.Unity mail address. After reading all these,I decided to give it a try and I contacted him via email and explained my problem to him. and he told me what to do and i did it then he did a Love spell for me. In just 26 hours, my husband came back to me and we solved our issues, we are even happier than before. Dr.Unity is really a gifted man and I will not stop testifying about him because he is a wonderful man and so powerful... if you are here and you need your Ex back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now and i guarantee you that he will help you. Here’s his contact: Email him at: Unityspelltemple@gmail.com , you can also call him or add him on Whats-app: +2348071622464 , you can also visit his website:http://unityspelltemple.webs.com , his blog:http://drunitytemple.blogspot.com . Miriam Michel / UK ..
Guest
2017-07-26 19:13:56 +0200
Now you can get ex-Lover back and stop a divorce or break-up…Even If Your Situation Seems Hopeless.! My husband said he no longer loved me at the end of May this year and i was hurt and heart broken i felt like my life was about to end and I almost committed suicide, I was emotionally down for a very long time. Thanks to a spell caster called Dr.Unity, which I meet online, on one faithful day, as I was browsing through the internet and I came across a lot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb, cure cancer and other sickness, some testified that he can cast a spell to stop divorce and so on. I also come across one particular testimony and it was about a woman called Tracey Hilton, she testified about how he brought back her Ex lover in less than 28 hours and at the end of her testimony she dropped Dr.Unity mail address. After reading all these,I decided to give it a try and I contacted him via email and explained my problem to him. and he told me what to do and i did it then he did a Love spell for me. In just 26 hours, my husband came back to me and we solved our issues, we are even happier than before. Dr.Unity is really a gifted man and I will not stop testifying about him because he is a wonderful man and so powerful... if you are here and you need your Ex back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now and i guarantee you that he will help you. Here’s his contact: Email him at: Unityspelltemple@gmail.com , you can also call him or add him on Whats-app: +2348071622464 , you can also visit his website:http://unityspelltemple.webs.com , his blog:http://drunitytemple.blogspot.com . Miriam Michel / UK ..
Guest
2017-05-30 08:04:53 +0200
Hey guys, I'm so excited of getting my husband back after he left me and our 3 kids for another woman. After 2 years of marriage, me and my husband has been into one quarrel or the other until he finally left me and moved to California to be with another woman. i felt my life was over and my kids thought they would never see their father again. i tried to be strong just for the kids but i could not control the pains that torments my heart, my heart was filled with sorrows and pains because i was really in love with my husband. Every day and night i think of him and always wish he would come back to me, I was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help get ex back fast. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a (Love spell) for me. 28 hours later, my husband really called me and told me that he miss me and the kids so much, So Amazing!! So that was how he came back that same day,with lots of love and joy,and he apologized for his mistake,and for the pain he caused me and the kids. Then from that day,our Marriage was now stronger than how it were before,All thanks to Dr Unity. he is so powerful and i decided to share my story on the internet that Dr Unity real and powerful spell caster who i will always pray to live long to help his children in the time of trouble, if you are here and you need your Ex back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now. Here’s his contact: Email him at: Unityspelltemple@gmail.com , you can also call him or add him on Whats-app: +2348071622464 , his website:http://unityspelltemple.yolasite.com , Jessica, 26 years, Texas, USA
Guest
2017-05-30 08:04:24 +0200
Hey guys, I'm so excited of getting my husband back after he left me and our 3 kids for another woman. After 2 years of marriage, me and my husband has been into one quarrel or the other until he finally left me and moved to California to be with another woman. i felt my life was over and my kids thought they would never see their father again. i tried to be strong just for the kids but i could not control the pains that torments my heart, my heart was filled with sorrows and pains because i was really in love with my husband. Every day and night i think of him and always wish he would come back to me, I was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help get ex back fast. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a (Love spell) for me. 28 hours later, my husband really called me and told me that he miss me and the kids so much, So Amazing!! So that was how he came back that same day,with lots of love and joy,and he apologized for his mistake,and for the pain he caused me and the kids. Then from that day,our Marriage was now stronger than how it were before,All thanks to Dr Unity. he is so powerful and i decided to share my story on the internet that Dr Unity real and powerful spell caster who i will always pray to live long to help his children in the time of trouble, if you are here and you need your Ex back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now. Here’s his contact: Email him at: Unityspelltemple@gmail.com , you can also call him or add him on Whats-app: +2348071622464 , his website:http://unityspelltemple.yolasite.com , Jessica, 26 years, Texas, USA
Guest
2017-05-10 21:00:49 +0200
I had doubts about magic spells after purchasing many spells that never worked I actually decided to never buy a spell again. I have tried different spell casters..Some of them never answered me after I paid and were obvious scammers, some really cast a spell but for some reason it didn't work. Then I saw a video on youtube with a person who was mentioning she had results with Mama Anita. Despite the suspicions I had her site looked real so I gave spells a last try. It's probably the best decision I ever made in my life because it worked and my boyfriend came back with me After I broke up with him I spent a lot of time wishing that I could just turn the clock backwards.He helped me do just that. In fact our relationship feels like the break up never even happened. We have never been this happy or passionate, all thanks to mama anita. If you're looking for a good spell caster look no further,you can contact her straight on (magic.lovespel@reincarnate.com).or (mama.anitaspellcraft@hotmail.com).
Donald
2017-05-06 18:31:11 +0200
Special thanks to the great spell caster called Dr Jatto, who have brought joy to me with his powerful spell, for more than 15months now me and my wife has been separated, since then i have done everything within my powers, i have visited severally places but all my efforts were wasted,until i saw a post of Dr Jatto restoring ex lover back, financial blessing and many more, and i decided to contact him and after writing to him on his email:drjattolovespelltemple@gmail.comordrjattolovespelltemple@yahoo.co.uk and after he gave me procedures on how he will help me he cast a love spell for me and that was how i got m wife back to me, contact Dr Jatto on his website:http://drjattolovespellte.wixsite.com/spelltemple or his mobile:+2347050270268.,
Guest
2017-04-14 17:28:07 +0200
BE CAREFUL HERE NOBODY CAN HELP YOU HERE OR EVEN SUGGEST HOW YOU CAN GET YOUR EX OR LOVE BACK,ANY TESTIMONIES OF MOST SPELL CASTER HERE MUST BE IGNORE.BECAUSE MOST OF THEM ARE SCAM I MEAN REAL SCAM WHICH I WAS A VICTIM AND I GOT RIPPED OF THOUSANDS OF DOLLARS BECAUSE I WAS SO ANXIOUS TO GET MY WIFE BACK AFTER SHE LEFT ME FOR OVER 2 YEARS WITH MY 7 YEARS OLD SON JERRY,I HAVE APPLIED TO 7 DIFFERENT SPELL CASTER HERE AND ALL TO NO AVAIL THEY ALL ASK FOR SAME THING SEND YOUR NAME YOUR EX NAME ADDRESS AND PICTURE PHONE NUMBER ETC WHICH I DID OVER AND OVER AGAIN AND MOST OF THEM WERE FROM WEST AFRICA UNTIL I SAW A POST ABOUT MAMA ANITA SPELL AND I DECIDED TO GAVE HER MY LAST TRAIL.SHE ASK ME FOUR THINGS MY REAL NAME,MY EX AND MY EX MOTHER NAME AND $380 AND SAID MY EX WILL COME BACK IN 24HOURS, I HAVE PAID OVER $3000 ON SPELL CASTING AND COURIER AND NOTHING HAVE WORK FOR ME AFTER 3 DAYS I WAS THINKING ABOUT HOW MUCH I HAVE LOST SO FAR SO I SAID LET ME GIVE HER A TRY SO I CALLED HER AGAIN AND SEND MY REAL NAME,MY EX AND MY EX MOTHER NAME AND THE $380 BECAUSE I SWEAR IT WAS MY LAST TRY SO I WAS WAITING AS SHE TOLD ME TO WAIT TILL NEXT DAY AND I COULD NOT SLEEP THAT NIGHT BECAUSE I REALLY LOVE MY WIFE AND WANT HER BACK AT 9PMTHAT DAY I SAW MY WIFE ON LINE ON FACE BOOK AND SHE SAID HI AT FIRST I WAS SHOCK BECAUSE SHE NEVER TALK WITH ME FOR THE PAST A YEAR AND 9 MONTH NOW I DID NOT REPLY AGAIN SHE SAID ARE YOU THERE? I QUICKLY REPLY YES AND SHE SAID CAN WE SEE TOMORROW I SAID YES AND SHE WENT OFF-LINE I WAS CONFUSED I TRY TO CHAT HER AGAIN BUT SHE WAS NO MORE ON LINE I COULD NOT SLEEP THAT NIGHT AS I WAS WONDERING WHAT SHE IS GOING TO SAY, BY 7.AM THE NEXT MORNING SHE GAVE ME A MISS CALL I DECIDED NOT TO CALL BACK AS I WAS STILL ON SHOCK AGAIN SHE CALL AND I PICK SHE SAID CAN WE SEE AFTER WORK TODAY I SAID YES SO SHE END THE CALL IMMEDIATELY I GOT OFF WORK SHE CALL ME AND WE MEET AND NOW WE ARE BACK AGAIN I CALL MAMA ANITA THE NEXT DAY THANKING HER FOR WHAT SHE HAS DONE IN FACT I STILL CALL HER AND THANK HER AS MY LIFE WAS NOT COMPLETE WITHOUT MY WIFE PLEASE BE CAREFUL HERE I HAVE BEEN SCAM THOUSANDS OF DOLLARS IF YOU WANT A TRUE LOVE SPELL THEN CONTACT MAMA ANITA (mamaanita.lovespellsolution@gmail.com) or mama.anitaspellcraft@hotmail.com or (magic.lovespel@reincarnate.com)
Guest
2017-02-15 09:31:10 +0100
Husband left me and my kids, i was passing though pains, sorrow, heartbroke, going crazy but this is how i restored happiness back in my life by getting my husband back. I’m Tiffany Wilson from UK. I'm happily married to a lovely and caring husband with two kids. A very big problem occurred in my family seven months ago,between me and my husband .so terrible that he took the case to court for a divorce. he said that he never wanted to stay with me again,and that he didn't love me anymore.So he packed out of the house and made me and my children passed through severe pain. I tried all my possible means to get him back,after much begging,but all to no avail.and he confirmed it that he has made his decision,and he never wanted to see me again. So on one evening,as i was coming back from work,i met an old friend of mine who asked of my husband .So i explained every thing to him,so he told me that the only way i can get my husband back,is to visit a spell caster,because it has really worked for him too.So i never believed in spell,but i had no other choice,than to follow his advice. Then he gave me the email address of the spell caster whom he visited.{templeofjoyandprosperity@gmail.com}. So the next morning,i sent a mail to the address he gave to me,and the spell caster assured me that i will get my husband back the next day.What an amazing statement!! I never believed,so he spoke with me,and told me everything that i need to do. Then the next morning, So surprisingly, my husband who didn't call me for the past 7 months,gave me a call to inform me that he was coming back.So Amazing!! So that was how he came back that same day,with lots of love and joy,and he apologized for his mistake,and for the pain he caused me and my children. Then from that day,our relationship was now stronger than how it were before,by the help of Dr Frank Ojo a spell caster. So, If you have any problem contact him, I give you 100% guarantee that he will help you, Thanks to Dr Frank Ojo for bringing back my husband ,and brought great joy to my family once again, so here his email address { templeofjoyandprosperity@gmail.com } Website address: http://lovespell2.yolasite.com, His Mobile number: +234)90- 39520524, He is a super natural Human and he is the best spell caster online contact him if you have any problem.
Guest
2017-02-15 09:19:45 +0100
Hello, i am Jessica Wayne from TX, USA. Life without my husband was a real mess for me and my children I am so happy to get my Ex back through the help of Dr Noble the spell caster . My greatest surprise was that 48 hours after the Doctor prepared the spell for me, my husband who has abandoned me for 4 years suddenly called me unexpectedly and am so happy that we have come to become one again through the help of Dr Noble and am so happy to be with my husband once again. Dr Noble is a very wonderful spell caster, you can contact him if you need his assistant because i know he can also help you. contact him through his email: templeofjoyandprosperity@gmail.com or call him on +2349039520524 immediately
Guest
2016-06-02 01:09:35 +0200
Hey guys, my name is Imelda Daher from Philippines but reside in America i am very happy that i was able to be online last week when Janet posted on YouTube that she has finally gotten what she wanted for her marriage life after all the stress she went through trying to hack into our husbands phone herself.. So after that I decided to try and see if it’s gonna work or still the same thing I see online everyday so I contacted Michael as i was referred to by Janet to his email which I did and got his direct telephone number as well too and believe me he did a good job for me that I was shocked when I got the information I needed that my dear husband for 10 year of marriage has a baby mama in Sweden. thanks to Michael Lawson for this great job even if it’s gonna break my home its better than been fooled for the rest of my life. lawsonmichael33@yahoo.com by Janet and he did a good and fast job for me in less than 48hrs...he made available phone hack, chat histories, present chats and future chats...You can also contact him for all sorts of mobile hacking jobs like he told me. Good luck to everyone who really wanna work with him and put a stop to the entire nightmare.
Guest
2016-04-03 03:48:57 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High monicaspiritualtemple@gmail.com anytime, he might be the answer to your problems. Here's his contact: monicaspiritualtemple@gmail.com or call him +2348134493948
Guest
2016-04-03 03:47:57 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High monicaspiritualtemple@gmail.com anytime, he might be the answer to your problems. Here's his contact: monicaspiritualtemple@gmail.com or call him +2348134493948
Guest
2016-04-03 02:14:14 +0200
'After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: spiritualherbalisthealing@gmail.com or call him +2349055637784 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS'
Guest
2015-12-30 09:28:53 +0100
Marriage restoration.. I lost my husband to another woman 2 weeks ago after 27 years of marriage . We had a lovely marriage but he started a relationship with a co worker who chased after him . He is living away near his work and her and refuses to talk to me or to come home . I am devastated and am finding it hard to cope . I wish I did not love him and that I could move on but I can't . I don't know how to stop feeling like this I wish I didn't as its eating me away and I m starting to feel ill. I have degraded myself begging him to come home all to no avail. I became very worried and needed help. As I was browsing through the internet one day, I came across a website that suggested that Dr Frank Ojo can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he did a spell for me. tow days later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again.. All thanks to Dr Frank Ojo . If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you. if you have any problem contact him, I give you 100% guarantee that he will help you, This is his details, E-mail: Templeofloveandprosperity@gmail.com , Web site: http://lovespell2.yolasite.com . Mobile number +2348072370762. Thank you all for reading.
Guest
2015-12-12 11:25:01 +0100
Hi everyone, I'm testify how i Got my Husband back after a Divorce !!! I'm Tiffany Wilson From California, after Five years of marriage, My Husband divorces me off no reason, I cried all through and try all the possible best I could to make everything work out for good and to get him back but to no avail, I was confused and frustrated until I crossed a site of Dr Frank Ojo, I read everything completely on the site, it was talking about Love spells and reunion marriage spells and different types of spells, I was more confused on what to do because I don’t believe on spell casters mostly on Love spells, though I decided to give a try out, I contacted Dr Frank Ojo and explained everything completely to him on what I am passing through to my own greatest surprise, Dr Frank Ojo told me that my husband is going to call me back to come home after two days he has finished casted the spell. I have believed on him and so surprising really my husband calls me back home and ask for forgiveness and he promised to Love me only and forever be with me only. All great thanks to Dr Frank Ojo for his marvelous spell work, contact him today by his Email: Templeofloveandprosperity@gmail.com ,website info: http://lovespell2.yolasite.com , If you have any problem contact him, I give you 100% guarantee that he will help you, Thanks to Dr Frank Ojo.
See also
Researchers at Johns Hopkins University have identified a gene which repressed in tumor cells, puts a halt to c... Read more
Tags: medicine , cancer
Cancer experts from Denmark have found an enzyme that seems to induce cancer senescence.... Read more
Tags: cancer , medicine
On 1 November 2013, Genentech announced that the U.S. Food and Drug Administration (FDA) approved Gazyva (obinu... Read more
Tags: cancer , leukemia , CLL , antibody , Genentech , Roche , chemoterapy