Hungarian researcher, Péter Horváth, cooperating with scientific group from the Institute of Biochemistry at the ETH Zurich have investigated the role of host cells during the infection of influenza A virus. It appeared that the virus is capable of mimicking host cell component. Because of this, what host cells do is assist in a process of capsid disassemble, which eventually results in entering of viral material into the nucleus. This recently identified mechanism gives hope for development of more efficient treatment directed against flu.
Influenza annual outbreaks occur usually in the winter months causing plenty of people suffering from complications, which sometimes might be really severe. The illness is strongly contagious and its spread is dependent on several factors such as virus transmissibility or the susceptibility of a particular population.
There exist several types of influenza viruses: A, B and C. Among them, A type possesses significant ability to rearrange its antigenic features, which are envelope glycoproteins, the hemagglutinin (H) and the neuraminidase (N). The subtypes of the glycoproteins are the basis of influenza virus nomenclature e.g. H1N1, popularly known as “swine influenza”. Due to the constant changes in the antigenic characteristics, the strains affecting people are different every year and the elaboration of efficient vaccine remains very challenging.
In the presented study, the researchers have tried to find potential targets for anti-viral drugs by analyzing the process of interaction between host cells and viral particles of influenza A. During the process of infection, capsids need to be disassembled before the viral ribonucleoproteins (RNPs) can become synthesized in the nuclei of the cells. The scientists have reported that histone-deacetylase 6 (HDAC6) is one of the major host proteins involved in this phenomenon. HDAC6 acts by connecting the viral capsid proteins with host motor proteins such as actin. Importantly, HDAC6 ubiquitin binding domain seems to be essential for the proper capsid uncoating and eventually efficient infection.
Yohei Yamauchi from the Institute of Biochemistry at the ETH Zurich, who is a co-author of the paper, explains in more detail how the infection can be blocked basing on the depicted mechanism:
“Theoretically in order to block infection, or to dampen it significantly, we want to develop a new drug or a nano-body that blocks the ubiquitin-binding activity of the HDAC6 ZnF-UBP region (which is at the C terminus of HDAC6). Since the structure of this particular domain has been already solved, we are hopeful that a small molecule inhibitor can be generated in time. When the ZnF-UBP is blocked, HDAC6 will not be able to asset the disassembly process of the flu capsid. HDAC6 is not the only cellular factor responsible for capsid disassembly, and we are working on some of those factors in parallel.”
This recent finding opens novel ways of struggling with flu. Researchers are intensively working on the elaboration of molecules that can serve as dugs. “We have recently begun to test delivery of antibodies or nanobodies into cells, which is currently under optimization.” said Yohei Yamauchi. It gives hope that in a not distant future, better approaches for fighting with the virus will be proposed and eventually applied in the clinics.
2016-08-05 08:07:22 +0200
Thank you so much Dr. Trust for restoring back my Broken marriage for 4 years of total separation with my lovely husband cos of her mistress who use a spell on him to abandoned me and our kids. i have contacted so many casters online several times but be scammed. i saw a testimony on the internet of one Juliana testifying of your good work, i contacted you which you assured me just 48 hours for an instant result. Sir just same 48 hours as you promise my husband came back home begging for forgiveness to love and cherish i and the kids forever, am so happy and thankful to you Dr. Trust,,,I am So Happy and Excited because as i am writing this Testimony, My husband is madly in love with me again. If there is any body Out there who is in Difficulties and need help should kindly Contact Dr. Trust on His Email ID and he is Ready to Help you no matter the Situation, (Ultimatespellcast@gmail.com or Ultimatespellcast@yahoo.com call +2348156885231) Web http://ultimatespellcast8.wix.com/ultimatespellcast
2016-04-03 04:37:44 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High firstname.lastname@example.org anytime, he might be the answer to your problems. Here's his contact: email@example.com or call him +2348134493948
2016-04-03 03:05:18 +0200
'After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: firstname.lastname@example.org or call him +2349055637784 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS'