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Nucleolin as a target for anti-cancer therapy

Nucleolin as a target for anti-cancer therapy

Publish date: 2014-12-05

Nucleolin, a multifunctional phosphoprotein present mainly in nucleolus, has drawn much attention of molecular biologists due to its role in carcinogenesis and potential of being attractive target for more efficient therapies. As current methods of cancer treatment are still highly unspecific, such approaches are strongly desired.

Tags: nucleolin , cancer , antibody , Bradford Goodwin , therapy

Nucleolin is a protein of many functions involved is such processes as transcription, cell proliferation and growth. It primarily resides in the nucleolus, which is the largest structure contained in the nucleus of eukaryotic cells, however, it can be also present in the cytoplasm and at the cell surface. It has been reported that nucleolin is especially stable in proliferating cells, whereas in inactive state it is subjected to the process of self-cleavage.

A localization of nucleolin in the cell determines its function. In the nucleolus it is mainly involved in rRNA synthesis, ribosome biogenesis and general control of DNA and RNA metabolism. In the cytoplasm, it governs the process of protein transportation and mRNA modification. At the cell surface, nucleolin serves as a receptor for different ligand molecules such as growth factors.

The recent findings put nucleolin on the list of potential anti-cancer targets. Concerning this aspect, it has been revealed that nucleolin ligands play crucial role in angiogenesis and tumorigenesis. CEO of Charleston Pharma (USA) Bradford Goodwin explains the idea of efficient therapy based on nucleolin, which can be promising target for antibodies.

Nowadays, the antibody-based treatment of cancer is the most promising approach in the oncology field. In order to provide more and more efficient therapies, the molecular events responsible for tumorigenesis have to be thoroughly examined and key antigens need to be identified. Therefore, novel therapeutic targets, such as nucleolin, increase our chances for successful fighting with various types of cancer.

Sources:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187884/

http://link.springer.com/article/10.1007%2Fs00432-014-1587-5

Maciej Smolarz

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