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Optimistic prospects for leukaemia treatment - Breakthroughs of Czech scientists

Optimistic prospects for leukaemia treatment - Breakthroughs of Czech scientists

Publish date: 2013-03-01

Leukaemia is a sort of the blood or bone marrow cancer. The main result of this serious disease is an abnormal increment in the number of immature white blood cells (blasts). There are two principal types of leukaemia; in case of the acute one the abundance of the blasts inhibits the formation of the healthy blood cells. After accumulation of malignant cells in the marrow cavity, they can spill into the bloodstream and spread to other organs. The chronic form of leukaemia requires longer period of time to progress and causes the build-up of the relatively health, but still anomalous white blood cells.

Tags: czech republic , medicine

Around 45% people suffering from leukaemia survive at least four years after the diagnosis. This number has tripled in the last forty years, but the recent breakthroughs of Czech scientists give a positive prospect for the future of leukaemia treatment. In September 2012 the research team from the Institute of Pathological Physiology of the 1st Medicine Faculty at Prague’s Charles University discovered that stem cells can be transplanted to people suffering from blood formation diseases even several hours after the donor’s death. Thanks to this finding, the number of bone marrow donors will be increased. It is especially good news since a very high level of immunogenetic congruence between the donor and the recipient is needed to perform transplantation and that is why the chances to find a suitable donor are significantly lessened. The Czech research team proved for the first time that “unlike other cells, stem cells taken even a number of hours after death fully preserve their natural qualities, and consequently they are suitable for transplant,” as Professor Necas said.

In February 2013 the next discovery of Czech scientists from the Institute of Molecular Genetics, this time, was announced. The researchers described so far unknown mechanism of how the malignant cells penetrate the bone marrow and enter the blood cells during acute myeloid leukaemia. The institute's head, Vaclav Horejsi, said: "Leukaemic cells kill the surrounding cells, thereby they create a certain canal and bite through to the blood where they start spreading in the whole body”.

The recent discoveries constitute a positive sign for the patients suffering from leukaemia and their practical application is only the matter of time.

 

Sources: 

http://publications.cancerresearchuk.org

http://praguemonitor.com/

http://www.biocev.eu/


by Jakub Chrustowicz

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