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Pharnext Announces Positive Topline Results from Pivotal Phase 3 Trial of PXT3003 for Treat

Pharnext Announces Positive Topline Results from Pivotal Phase 3 Trial of PXT3003 for Treatment of Charcot-Marie-Tooth Type 1A Disease

Publish date: 2018-10-16

Pharnext SA, a biopharmaceutical company pioneering a new approach to the development of innovative drug combinations based on big data genomics and artificial intelligence, today announced positive topline results from its pivotal Phase 3 clinical trial (PLEO-CMT) evaluating two doses of PXT3003 compared to placebo during 15 months for the treatment of Charcot-Marie-Tooth type 1A disease (CMT1A).

Tags: clinical trials , Pharnext SA

PLEO-CMT was a pivotal, 15-month, double-blind Phase 3 study that assessed the efficacy and safety of PXT3003 compared to placebo for the treatment of patients with mild to moderate CMT1A. The study evaluated 2 doses of PXT3003, and patients were randomized 1:1:1. The study enrolled 323 patients aged 16 to 65 years in 30 sites across EU, USA and Canada. The primary endpoint was the Overall Neuropathy Limitation Scale (ONLS) measuring patient disability, in agreement with FDA and EMA for this pathology. A reduction of 0.3 point on this scale was determined to be meaningful according to previously described methodology.
 
Characteristics of the three groups were comparable at baseline. For endpoint analysis, there were 87 patients in placebo, 93 patients in lower dose and 55 patients in higher dose arms at baseline. The lower number of patients in the higher dose is due to unexpected formulation/ stability issues. Nevertheless, compelling results were obtained: compared with placebo, a mean reduction of 0.4-point ONLS (95% CI [0.1,0.6], p=0.008)was observed in the higher dose group. A sensitivity analysis demonstrated the consistency of this result across various statistical models. The secondary endpoints confirmed the superiority of the higher dose, in particular the improvement on the 10-meter walk test with a reduction of 0.5 sec (95%CI [0.1,0.9], p=0.016). A linear dose effect was observed. PXT3003 was safe, well tolerated and showed a similar safety profile as seen in the Phase 2 study. 
 
In this study, PXT3003 provided first evidence of a meaningful improvement of CMT1A patients in showing a statistically significant amelioration on the ONLS disability scale (primary endpoint) confirmed by sensitivity analysis and secondary endpoints together with a good safety profile. Based on these results Pharnext intends to file for market approval in the US and EU. The statistical plan and the results have not yet been reviewed by the regulatory bodies.
 
Pharnext initiated a 9-month, open-label, follow-up extension study, PLEO-CMT-FU, in March 2016 that is currently ongoing with patients who completed the PLEO-CMT study. It is designed to confirm the long-term safety and tolerability of PXT3003 with results expected in H2 2019.
 
Pharnext also expects to initiate a Phase 3 trial of PXT3003 in pediatric CMT1A patients in the first half of 2019, based on a Pediatric Investigation Plan (PIP) agreed upon with the EMA. The results of this trial are not needed for market approval for the adult indication.
 
"We are thrilled with the outcome of the trial and with the clearly demonstrated efficacy of PXT3003 in addressing the debilitating disease progression of CMT1A. We look forward to working closely with regulatory agencies to bring this therapy to patients," said Professor Daniel Cohen, MD, PhD, Pharnext's Co-Founder and Chief Executive Officer. "These results validate the broad potential of our PLEOTHERAPYTMdrug discovery platform in other neurodegenerative and other disorders and, of course, represent a tremendous milestone for Pharnext."
 
"CMT1A is a chronic, severe and debilitating inherited condition affecting about 125,000 people in the USA and EU, and, until now, there has been no prospect of effective pharmacological treatment," said David Cornblath, MD, Professor of Neurology, Johns Hopkins University, Baltimore, Maryland. "In this trial, PXT3003 demonstrated a significant improvement in patients with mild-to-moderate CMT1A and provided encouraging results that indicate PXT3003 may change the treatment paradigm for the disease. As a clinician, I am excited about the therapeutic potential of PXT3003 and what it means for CMT1A patients and their families."
 
"This is the first large multi-center trial that has demonstrated a positive effect in CMT," said Richard Lewis, MD, Professor of Neurology, Cedars-Sinai Medical Center, Los Angeles, California. "I am delighted that this safe and novel approach may be available to patients with CMT1A."
 
"These results are the first direct translation of a preclinical treatment developed in animal models to CMT1A patients," said Michael Sereda, MD, Professor of Neurology at the Max-Planck Institute of Experimental Medicine, Göttingen, Germany. "I am impressed by the consistency of the therapeutic effect in both preclinical and clinical trials. Data derived from CMT rat models give us important insight regarding the effect of PXT3003 on the diseased peripheral nervous system in CMT1A."
 
Pharnext would like to express its gratitude to the investigators and their teams and to the patients and their families for their commitment to this trial. 

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2018-12-04 14:29:59 +0100
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Guest
2018-12-04 14:29:44 +0100
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Guest
2018-12-03 02:06:36 +0100
Excited, My Girlfriend Is Back Am Alexis scorpio from FL Usa my girlfriend cheated on me and asked for breakup. I don't believe at first i try to get back with her but all she told me was she’s with someone else. that she is no longer interested in marrying me at that point i was heart broken coz i love my girlfriend so much that i could not let go off her all of a sudden she left me, i really love her and never can imagine my life without her. not until i came across a powerful real spell caster Dr happy who promise me 24hours urgent love spell to get back with my girlfriend, good twenty-four {24} hours. hmm-mm, it was a good night time at 11:pm within the days that Dr happy told me that my girlfriend will be back, at first i heard the bell rings getting close to my door i heard someone saying honey!!!, it sound familiar i opened the door and i saw my girlfriend standing and weeping in front of me. i was not surprised because its all i have been praying for her to come back home. Guess what 2 weeks after she noticed her system and her body temperature was changed and i took her to clinic for check up and the doctor told me that there is life in her which means she was pregnant i really wants to use this opportunity to thanks Dr happy so much and the love page that directed me to Dr happy if you have any problem getting your ex back, or predicament that is worse or exactly like this you have been into, contact Dr happy on happylovespell2@gmail.com Whatsapp/cal +2348133873774 visit his website...happylovespell2.webnode.com/ about his love spell Blogs site.http://happylovespel.blogspot.com.ng/
Guest
2018-12-02 17:24:39 +0100
Excited, My Girlfriend Is Back Am Alexis scorpio from FL Usa my girlfriend cheated on me and asked for breakup. I don't believe at first i try to get back with her but all she told me was she’s with someone else. that she is no longer interested in marrying me at that point i was heart broken coz i love my girlfriend so much that i could not let go off her all of a sudden she left me, i really love her and never can imagine my life without her. not until i came across a powerful real spell caster Dr happy who promise me 24hours urgent love spell to get back with my girlfriend, good twenty-four {24} hours. hmm-mm, it was a good night time at 11:pm within the days that Dr happy told me that my girlfriend will be back, at first i heard the bell rings getting close to my door i heard someone saying honey!!!, it sound familiar i opened the door and i saw my girlfriend standing and weeping in front of me. i was not surprised because its all i have been praying for her to come back home. Guess what 2 weeks after she noticed her system and her body temperature was changed and i took her to clinic for check up and the doctor told me that there is life in her which means she was pregnant i really wants to use this opportunity to thanks Dr happy so much and the love page that directed me to Dr happy if you have any problem getting your ex back, or predicament that is worse or exactly like this you have been into, contact Dr happy on happylovespell2@gmail.com Whatsapp/cal +2348133873774 visit his website...happylovespell2.webnode.com/ about his love spell Blogs site.http://happylovespel.blogspot.com.ng/
Guest
2018-12-01 16:04:53 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:53 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:53 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:52 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:52 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:52 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:51 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:51 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 16:04:51 +0100
Hello my name is Lauren i'm from USA i want to testify of a great and powerful spell caster my husband left me and the kids for 2 weeks when i called him he didn't pick up when he came back home the 3rd week he told me he wanted a divorce i was so sad i cried all night he left again i was so lonely the next day i was searching for something online when i found a spell caster called Priest Ade who have helped so many people with their problems so i contacted him with my problems he told me it will take 24hrs and my husband will be back to me i did every thing he told me to do and the next day my husband came back kneeling and begging he canceled the divorce we are now happy together Priest Ade can help you too Email him at ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: http://ancientspiritspell.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465
Guest
2018-12-01 11:29:41 +0100
Excited, My Girlfriend Is Back Am Alexis scorpio from FL Usa my girlfriend cheated on me and asked for breakup. I don't believe at first i try to get back with her but all she told me was she’s with someone else. that she is no longer interested in marrying me at that point i was heart broken coz i love my girlfriend so much that i could not let go off her all of a sudden she left me, i really love her and never can imagine my life without her. not until i came across a powerful real spell caster Dr happy who promise me 24hours urgent love spell to get back with my girlfriend, good twenty-four {24} hours. hmm-mm, it was a good night time at 11:pm within the days that Dr happy told me that my girlfriend will be back, at first i heard the bell rings getting close to my door i heard someone saying honey!!!, it sound familiar i opened the door and i saw my girlfriend standing and weeping in front of me. i was not surprised because its all i have been praying for her to come back home. Guess what 2 weeks after she noticed her system and her body temperature was changed and i took her to clinic for check up and the doctor told me that there is life in her which means she was pregnant i really wants to use this opportunity to thanks Dr happy so much and the love page that directed me to Dr happy if you have any problem getting your ex back, or predicament that is worse or exactly like this you have been into, contact Dr happy on happylovespell2@gmail.com Whatsapp/cal +2348133873774 visit his website...happylovespell2.webnode.com/ about his love spell Blogs site.http://happylovespel.blogspot.com.ng/
Sherrywaljer
2018-11-27 11:55:00 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:55:00 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:55:00 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:55:00 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:54:59 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:48:49 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:48:49 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:48:48 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:48:48 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:48:48 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Sherrywaljer
2018-11-27 11:48:48 +0100
My name is SHERRY WALJER from USA Massachusetts, i want to testify to the general public how my relationship was restored back by the great power's of Dr Larry after three months of loneliness, my ex-lover called me after my contact with Dr Larry that he want us to come back and start a good home, now we are happily together again as lovers. All thanks to Dr Larry who did a love spell for me for my ex lover to return home. I will keep sharing this until people who also need help see this for his wonderful help. You can contact him on his via email assurancesolutionhome@gmail.com or whatsapp him on +1(424)-261-8520. https://assurancesolutionhome.blogspot.com website http://assurancesolutionhome.website2.me/ youtube https://youtu.be/4shxcyUlqtg
Guest
2018-11-23 13:25:59 +0100
My name is Benita Willson from GERMANY, I want to quickly tell the world that there is a real spell caster that is powerful and genuine, His name is Dr Ken He helped me recently to reunite my relationship with my husband who left me, When i contacted Dr Ken he cast a love spell for me and my husband who said he doesn't have anything to do with me again called me and started begging me. he is back now with so much love and care. today i am glad to let you all know that this spell caster have the powers to bring lovers back. because i am now happy with my husband. To anyone who is reading this article and needs any help, Dr Ken can help...You can contact him Via this email greatdrkenspelltemple@gmail.com or via WhatsApp with this number +2348104557346
Guest
2018-11-22 01:23:03 +0100
Hello every one out here.... My name is ledan , I'm from North Carolina USA. i want to use this opportunity to thank my great spell caster who really made my life a pleasurable today. This great man PRIEST WISDOM brought my husband back to me, i had three lovely kids for my husband, about four years ago i and my husband has been into one quarrel or the other until he finally left me for one lady. i felt my life was over and my kids thought they would never see their father again. i tried to be strong just for the kids but i could not control the pains that torments my heart, my heart was filled with sorrows and pains because i was really in love with my husband. Every day and night i think of him and always wish he would come back to me, until one day i met a good friend of mine that was also in a situation like me but her problem was her ex-boyfriend who she had an unwanted pregnancy for and he refused to take responsibility and dumped her. she told me that mine was a small case and that i should not worry about it at all, so i asked her what was the solution to my problems and she gave me this great man email address. i was doubting if this man was the solution, so i contacted this great man and he told me what to do and i deed them all, he told me to wait for just two day and that my husband will come crawling on his kneels just for forgiveness so i faithfully deed what this great man asked me to do and for sure after two days i heard a knock on the door, in a great surprise i saw him on his kneels and i was speechless, when he saw me, all he did was crying and asking me for forgiveness, from that day, all the pains and sorrows in my heart flew away,since then i and my husband and our lovely kids are happy.that's why i want to say a big thank you to PRIEST WISDOM . This great man made me to understand that there is no problem on earth that has no solution so please if you know that you have this same problem or any problem that is similar, i will advise you to come straight to this great man. you can email him at: supernaturalspell1@gmail.com And also Reach him on WhatsApp Number: +2348124644470 Thanks PRIEST WISDOM
Guest
2018-11-20 05:15:25 +0100
TESTIMONY OF A GREAT SPELL CASTER PRIEST WISDOM My name is Clara Bambi . This is a testimony of a great spell caster 'PRIEST WISDOM' who helped me in restoring my love life back. The day my husband left me, things appeared bleak, and the atmosphere was heavy with uncertainties. Everything seemed pale and so I decided to look for help in spell casters who have the capability to bring my ex husband back to me. As envisaged, I went on the internet and as you too have seen in your search for a reliable spell caster, I saw a lot of testimonies being done by spell casters in the recovery of ex husbands and loved ones. Driven by belief in PRIEST WISDOM, I contacted him and after explaining things to him, he accepted to face the challenges on ground. He did brilliantly well. My ex husband is back to me with more care and affection. I will therefore like to take this opportunity to pay tribute to him for his selfless service to my situation. Commendable, he showed great courage at taking on the daunting task of finding solutions to practically any given problem. Contact him at supernaturalspell1@gmail.com OR whatsapp him +2348124644470 and I believe he won't fail you too.
Guest
2018-11-14 07:22:31 +0100
Hello! Greetings from Vanessa Rose. Love spell from Dr. Mako brought my husband back" After 9years of marriage, my husband was having an affair with a co-worker and i love my husband so much but he was cheating on me with another woman and this lady i think use witchcraft or black magic on my husband to make him hate me and my kids and this was so critical and uncalled-for, I cry all day and night for God to send me a helper to bring back my husband! I was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Mako can help get ex back fast. So, I felt I should give him a try. I contacted him and he told me what to do and i did it, then he did a lovespell for me. 28 hours later, my husband really called me and told me that he miss me so much, Oh My God! i was so happy, and today i am happy with my man again and we are joyfully living together as one big family and i thank the powerful spell caster Dr. Mako, he is so powerful and i decided to share my story on the internet that Dr. Mako is best spell caster online who i will always pray to live long to help his children in the time of trouble, if you are here and your lover is turning you down, or your husband moved to another woman, do not cry anymore, contact Dr.Mako at his email: Makospelltemple@yahoo.com or WhatsApp him: +2347054263874 ,to help you in getting your Ex lover back or Stop your divorce and save your marriage now.
Guest
2018-11-10 20:50:19 +0100
heal from broken heart" Love spell from dr.Unity brought my husband back √√√ I’m so excited of getting my husband back after he left me for another woman.contact Dr.Unity at Unityspelltemple@gmail.com or call/WhatsApp him: +2348071622464 to help you in getting your Ex lover back or Stop your divorce and save your marriage now
Guest
2018-11-04 00:16:58 +0100
HOW I GOT MY HUSBAND BACK WITH THE HELP OF PRIEST WISDOM CONTACT PRIEST WISDOM ON WHATSAPP NUMBER +2348124644470 This is my testimony about the good work of priest wisdom who help me.... I'm ann Earnis from norht carolina USA. And am sorry for putting this on net but i will have to, by this world best spell caster that brought back my husband who left me out for past 3 years, i eventually met this man on a blog site posting by one of is client for help, i explained everything to him and he told me about a spell caster that he had heard about and he gave me an email address to write to the spell caster to tell him my problems. In just 2 days, my husband was back to me. I just want to say thank you to this truthful and sincere spell caster, sir all you told me have come to pass and thank you sir. Please i want to tell everyone who is looking for any solution to their problem, i advice you to kindly consult this spell caster, he is real,he is powerful and whatever the spell caster tell is what will happen, because all what the spell caster told me came to pass. You can kindly contact him on: his email address is supernaturalspell1@gmail.com or directly on whasapp +2348124644470 or call. PRIEST WISDOM Blog Website: https://supernaturalspell1.blogspot.com/ or http://reallovespellcaster.over-blog.com
Guest
2018-11-03 08:11:05 +0100
Excited, My Girlfriend Is Back Am Alexis scorpio from FL Usa my girlfriend cheated on me and asked for breakup. I don't believe at first i try to get back with her but all she told me was she’s with someone else. that she is no longer interested in marrying me at that point i was heart broken coz i love my girlfriend so much that i could not let go off her all of a sudden she left me, i really love her and never can imagine my life without her. not until i came across a powerful real spell caster Dr happy who promise me 24hours urgent love spell to get back with my girlfriend, good twenty-four {24} hours. hmm-mm, it was a good night time at 11:pm within the days that Dr happy told me that my girlfriend will be back, at first i heard the bell rings getting close to my door i heard someone saying honey!!!, it sound familiar i opened the door and i saw my girlfriend standing and weeping in front of me. i was not surprised because its all i have been praying for her to come back home. Guess what 2 weeks after she noticed her system and her body temperature was changed and i took her to clinic for check up and the doctor told me that there is life in her which means she was pregnant i really wants to use this opportunity to thanks Dr happy so much and the love page that directed me to Dr happy if you have any problem getting your ex back, or predicament that is worse or exactly like this you have been into, contact Dr happy on happylovespell2@gmail.com Whatsapp/cal +2348133873774 visit his website...happylovespell2.webnode.com/ about his love spell Blogs site.http://happylovespel.blogspot.com.ng/
Guest
2018-10-24 19:15:19 +0200
My name is ethan micheal ,am from USA.i want to share my wonderful testimony on how i got back my husband back, who i sworn ever to be with until when he left me to another woman for no reason and i try to make things work for both of us yet things where getting worse and i love him so much and there is nothing i could do to get my husband back until i met a testimony share by a woman called Stella tea from Australia on the internet talking about a powerful spell caster who brought her husband back within 24hours and i decide to give it a try and to my greatest surprise he also did it for me just as he did for Stella and i have a lot of people complaining of fake spell caster but this one i met was a real spell caster who help me to solve my problem i have no solution to,i introduce many of my best friends that have a similar problems,and their problem were solve with the great help of PRIEST WISDOM .who help them to get back their lovers within 24 hours.i am so happy that my husband is back to me again,and the most surprising thing is that our love is very strong,every day is happiness and joy. and there is nothing like been with the man you love.i am so happy my love is back to me with the help of PRIEST WISDOM if you have similar problem i will advice you to contact him ,he is there to help you and put a smile on your face as he did to me and others.contact email supernaturalspell@yahoo.COM or supernaturalspell1@gmail.com you can call /whatsapp him through is mobile number +2348124644470 https://supernaturalspell1.blogspot.com/ http://reallovespellcaster.over-blog.com THIS MY BLOG https://ethanmicheal1.blogspot.com/
Guest
2018-10-24 19:14:15 +0200
My name is ethan micheal ,am from USA.i want to share my wonderful testimony on how i got back my husband back, who i sworn ever to be with until when he left me to another woman for no reason and i try to make things work for both of us yet things where getting worse and i love him so much and there is nothing i could do to get my husband back until i met a testimony share by a woman called Stella tea from Australia on the internet talking about a powerful spell caster who brought her husband back within 24hours and i decide to give it a try and to my greatest surprise he also did it for me just as he did for Stella and i have a lot of people complaining of fake spell caster but this one i met was a real spell caster who help me to solve my problem i have no solution to,i introduce many of my best friends that have a similar problems,and their problem were solve with the great help of PRIEST WISDOM .who help them to get back their lovers within 24 hours.i am so happy that my husband is back to me again,and the most surprising thing is that our love is very strong,every day is happiness and joy. and there is nothing like been with the man you love.i am so happy my love is back to me with the help of PRIEST WISDOM if you have similar problem i will advice you to contact him ,he is there to help you and put a smile on your face as he did to me and others.contact email supernaturalspell@yahoo.COM or supernaturalspell1@gmail.com you can call /whatsapp him through is mobile number +2348124644470 https://supernaturalspell1.blogspot.com/ http://reallovespellcaster.over-blog.com THIS MY BLOG https://ethanmicheal1.blogspot.com/
Guest
2018-10-24 16:44:37 +0200
heal from broken heart"contact Unityspelltemple@gmail.com for urgent effective love Spell to get your ex lover back now. After 12years of marriage, me and my husband has been into one quarrel or the other until he finally left me and moved to California to be with another woman. I felt my life was over and my kids thought they would never see their father again. i tried to be strong just for the kids but i could not control the pains that torments my heart, my heart was filled with sorrows and pains because i was really in love with my husband. Every day and night i think of him and always wish he could come back to me, I was really worried and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help get ex back fast. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a Love spell for me. 28 hours later, my husband really called me and told me that he miss me and the kids so much, So Amazing!! So that was how he came back that same day,with lots of love and joy,and he apologized for his mistake,and for the pain he caused me and the kids. Then from that day,our Marriage was now stronger than how it were before, All thanks to Dr Unity. he is so powerful and i decided to share my story on the internet that Dr.Unity is real and powerful spell caster who i will always pray to live long to help his children in the time of trouble, if you are here and you need love spell to get ex lover back forever or save your marriage fast. Do not cry anymore, contact this powerful spell caster Dr.Unity now. Here’s his contact:Call/WhatsApp: +2348071622464 ,Email: Unityspelltemple@gmail.com ,Website:https://unityspellstemple.blogspot.com ,your kindness will never be forgotten.
Guest
2018-10-23 17:22:58 +0200
Hi everyone I'm from Texas USA. Am here to testify of a great and powerful spell caster named DR AKERECO of drakerecospellcaster@gmail.com I was so confused and devastated when my boyfriend left me for another girl. I needed him back desperately because i loved him so much. So i contacted this great spell caster for a help. He helped me cast a return love spell on him and just within 2 days my boyfriend came back to me crying and begging for my forgiveness. I want to recommend this great spell caster to anyone that truly needs an urgent solution to a love break up. Simply contact the great DR AKERECO via email: drakerecospellcaster@gmail.com His whats-app +1628-203-8649 Website http://drakerecoproblemssolutionhome.webs.com
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