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Polyunsaturated fatty acids – friends or foes? RETROTOPE strikes back.

Publish date: 2016-06-06

Retrotope is an American biotechnology company which has a real chance to introduce to the marker the efficient drug against neurodegenerative diseases. Work area of Retrotope are therapies of metabolic diseases connected to oxidative stress conditions and lipid oxidation. Developed drug is currently in initial phase of clinical trials. The newest research results were presented during the Biotech Solutions for Health and Environment: MOBI4Health Conference & New IFB Building Opening, held 12-15 April in Gdansk, Poland.

Tags: MOBI4Health , Retrotope , polyunsaturated fatty acids , linoleic acid , reactive oxygen species

Retrotope company was founded in 2006 with private funds of Dr. Robert J Molinari, Prof. Charles Cantor and Mikhail Shchepinov. The research subject of Retrotope is aging and connected neurodegenerative processes often resulting from oxidative stress conditions. However, the company itself does not have any laboratories, factories or equipment. It is a virtual company based on cooperation with over a dozen of research partners. What is unique in Retrotope which makes it more successful than other pharmaceutic companies and why their drug candidate has a real chance to pass clinical trials? Drug RT001 is now in Phase I and II clinical trials as a candidate for Friedreich’s ataxia (FA) patients bringing very promising results. But let’s start from the beginning…

Oxygen fate

Oxygen is obligatory for life. Unfortunately, there is a second part of the story – at the same time it is a cause of metabolic oxidative stress and damages present mainly in mitochondria. It is estimated, that as much as 5% total energy of human organism is consumed to repair those oxidation damages resulting mainly from peroxidation of polyunsaturated fatty acids (PUFAs). But aren’t PUFAs a good fellows associated with a good health? Plant oils and famous omega acids present in fish are only few examples of PUFAs which should be eaten in high amounts. Are then PUFAs our friends or foes?

It is assumed, that relatively fast evolutional development of humans has begun when our ancestors stared to eat seafood, which is connected to beneficial impact of omega acids on brain development. However, the paradox of life is that the cause of our development is at the same time the cause of our aging and death. PUFAs are the target of peroxidation – a radical reaction of fatty acids oxidation, which products lead to damage od lipids, proteins and nucleic acids.

Why present attempts to treat neurodegenerative diseases fail?

There are probably many causes, but the crucial issue is the slow progression of the disease combined with the relative insensitivity of accepted clinical endpoints. Therefore, no drug has so far succeeded in showing sufficient efficacy to get regulatory approval, as far as FA is considered. The second important cause is a hermeticity of blood-brain barrier, which for many candidates is impassable.

Founders of Retrotope decided to solve the problem from the other side. Generation of reactive oxygen species is unavoidable – therefore, maybe we should not get rid of a primary cause of oxidative stress, but rather get rid of its target? Presented strategy is to prevent free radicals from PUFAs peroxidation. How? Very easily…

New drug for old disease

Friedreich’s ataxia is an orphan disease of a genetic background leading to a progressive degeneration of nervous system and heart muscle. The cause is a severe deficiency of frataxin – a mitochondrial protein participating in iron metabolism. Then frataxin is lacking, free iron is accumulated and high amounts of free radicals are generated in a classical Fenton’s reaction. As a result, free radicals cause lipid peroxidation and damage of mitochondria.

Peroxidation of unsaturated fatty acids occurs in defined chain position – it is initiated with “stealing” an electron from a highly reactive hydrogen atoms localized next to methylene bridge adjacent to a double bond. A novel strategy of prevention and treatment is to chemically modify the lipids, therefore to substitute the neuralgic hydrogen with deuterium, its heavy isotope. This approach is a real success – deuterated lipids do not undergo peroxidation and are efficiently accumulated in organism. Experiments with the use of animals showed efficient exchange of “normal” dietary fatty acids in brain, liver and retina, revealing no toxicity or behavioral changes.

Drug RT001 is a deuterated form of linoleic acid – 11.11-dideuterolinoleic acid. It was shown that very small amount of drug – thus 20% replacement in a whole linoleic acid content – prevents from peroxidation of lipids in cell membranes. RT001 is currently in Phase I and II clinical trials. The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of RT001 in patients with Friedreich's ataxia. The study is currently recruiting participants. In the future, deuterated PUFAs can be used to treat other diseases such as Parkinson’s and Alzheimer disease or diabetic retinopathy.

Ref. Hill S. et al. 2012

Last achievements of Retrotope were presented during the Biotech Solutions for Health and Environment: MOBI4Health Conference & New IFB Building Opening held 12-15 April in Gdansk, Poland. The talk about the genesis and efficient strategy to fight oxidative stress was given by Prof. Charles Cantor – a prominent molecular biologist, inventor and a habitué of events associated with MOBI4Health project.

Photo-review from a conference and opening ceremony of a new building of Institute of Biotechnology is available below:

https://www.facebook.com/MWB.UGiGUMed/posts/499759103559116

http://www.gdansk.pl/urzad/galeria?c=4381

Sources:

Monika Kossakowska-Zwierucho

 

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2018-10-08 15:55:06 +0200
After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: spiritualherbalisthealing@gmail.com or call him +2348164728160 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS
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2018-02-24 19:27:28 +0100
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2017-05-16 22:22:43 +0200
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Guest
2017-03-28 23:23:58 +0200
Hello, My wife and I have been married for 15 years. For over five years I have been dealing with jealousy issues because of flirting and her having emotional type affairs with other men. I felt like my masculinity was in question and if I said the way she was acting bothered me, it seemed to make matters worse or I was accused of being controling. During this period I did state I wanted a divorce if the behavior was not going to end: texting men a night, leaving for the weekend without letting me know where she was going or not responding to messages. We do have a son and basically it's been him and I for the last year on the weekends. She disconnected completely from being a good wife and mother. In April she said she wanted a separation and I said no we need to get into marriage counseling. We did try that, but she was not very responsive and didn't give any effort. Afterward she was adamant about separation and divorce. I continued to say no and that we needed to save our family. She presented a separation agreement and I had to hire a lawyer. Because of the above behavior my lawyer suggested a private investigator. The investigator discovered my wife was having an affair with a close friend of the family who also is married with children. We know the extended families. I feel like I should tell this man's wife about what happened. This adultery has devastated me emotionally, I feel betrayed and I'm physically drained. I know my wife is passionate in terms of her sexuality, and I can't get the thought of them out of my head. It makes me question my own manhood, and I feel very inferior or that he must be a better lover or what ever. The problem is my wife pursued him. She would go to him and she lured him into this adultery. I felt this was coming for some time and could not stop it. She was not only lying to me but also to our son about what she was doing and where she was going. My family is important, my son loves her and as crazy as it sounds so do I. Can you respond with a course of action on how to proceed? I was still have a very huge place in my heart for her. so i searched for help online and I came across a website that suggested that Dr Ahmed can help solve marital problems, restore broken relationships and so on. So I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a spell for me. 28 hours later, my wife came to me and apologized for the wrongs she did and promise never to do it again. Ever since then, everything has returned back to normal. I, my son and my wife are living together happily again.. All thanks to Dr Ahmed. as it is a place to resolve marriage/relationship issues, do you want to be sure if your spouse is being faithful to you or Do you want your Ex to come back to you Contact.: E-mail: Ahmedutimate@gmail.com or call/Whats-app: +2348160153829 save your crumbling home and change of grades its 100% safe. I suggest you contact him. He will not disappoint you. David L. Ollis, 43yrs, UK
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2017-03-04 01:24:44 +0100
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Guest
2017-02-27 08:42:22 +0100
Good day everyone. I have something to share with you.. my wife and I were separated for a long period due to some misunderstanding, I came across different spell casters and they were all unable to bring my lover back. I was so sad and almost gave up on him when i met a spell caster called Dr iruwa, who helped me get my lover back. Ever since then i have been so happy and couldn't believe it would happen. He also helped me with success spell, I have been living happily with my lover now and we are married. Here is his contact iruwa567@gmail.com if you need his help on getting your ex back, stop your marriage from crumbling, or you need success in every aspect of your life. He is really a good spell caster.E-mail:iruwa567@gmail.com watsapp +27633647906 website:www.superiorquickspellsolution.com
Guest
2017-02-17 10:01:09 +0100
Good day,,,, Read my testimony!!! Getting ex back after a breakup. Am Cora L. Sanchez 30 from UK, my boyfriend of a 2year just broke up with me and am 28 weeks pregnant. I have cried my self to sleep most of the nights and don’t seem to concentrate during lectures sometimes I stay awake almost all night thinking about him and start to cry all over again. Because of this I end up not having energy for my next day’s classes, my attendance has dropped and am always in uni and on time. Generally he is a very nice guy, he ended it because he said we were arguing a lot and not getting along. He is right we’ve been arguing during the pregnancy a lot. After the break up I kept ringing him and telling him I will change. I am in love with this guy and he is the best guy I have ever been with. I’m still hurt and in disbelief when he said he didn’t have any romantic feelings towards me anymore that hurt me faster than a lethal syringe. He texts me now and then mainly to check up on how am doing with the pregnancy, he is supportive with it but it’s not fair on me, him texting me as I just want to grieve the pain and not have any stress due to the pregnancy. i was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Ahmed can help solve marital problems, restore broken relationships and so on. So I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a spell for me. 22 hours later, my boyfriend came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my boyfriend are living together happily again.. All thanks to Dr Ahmed. as it is a place to resolve marriage/relationship issues, do you want to be sure if your spouse is being faithful to you or Do you want your Ex to come back to you Contact.: E-mail: Ahmedutimate@gmail.com or call/Whats-app: +2348160153829 save your crumbling home and change of grades its 100% safe. I suggest you contact him. He will not disappoint you.
Enoch davies
2016-12-21 21:10:31 +0100
GET YOUR EX WIFE, EX GIRLFRIEND, EX BOYFRIEND AND SOLVE ALL TYPE OF PROBLEM THROUGH COVENANTSOLUTIONTEMPLE@GMAIL.COM. My name is Enoch Davies .my wife and I got married 6 years ago and we were so much in love with each other, we have 2 kids(josh and rebecca). One day my wife came back home from her friends place and she told me that she wants us to file for a divorce that she's no longer interested in our marriage, i was surprise and everything seem to me like a joke. after then i tried all my best to get her back but there was no way. but to no avail, my heart was broken, i wondered whats happening .i was on facebook when i saw a post on how Dr Ewan helped a lady to bring back her lost husband. i was scared but because i love my wife so much and I am ready to do anything to bring her back. I decided to give it a try by contacting him via email:covenantsolutiontemple@gmail.com, So when i contacted him i narrated everything to him and he said my case is not a serious one that my husband will come back to me within 18 hours if i believe in his power.he told me to do some things to do which i did before 18 hours, my wife called me on phone and was crying for forgiveness. right now we are now a new branded family with more happiness, we are even going on vacation on xmas. please if any one of you out there is passing through same issue in your marriage, relationship issues contact Dr Ewan today or call or add him on whatsapp on +234905735398 . contact him today on covenantsolutiontemple@gmail.com now. . I will keep on sharing the good news about this. Thanks Dr.
Guest
2016-11-09 13:09:30 +0100
Getting ex boyfriend back after a breakup,I’m extremely happy that will are living together again. Am Maria 21yr from England, my boyfriend of a 4yr just broke up with me and am 30 weeks pregnant.I have cried my self to sleep most of the nights and don’t seem to concentrate during lectures sometimes I stay awake almost all night thinking about him and start to cry all over again.Because of this I end up not having energy for my next day’s classes ,my attendance has dropped and am always in uni and on time.Generally he is a very nice guy ,he ended it because he said we were arguing a lot and not getting along.He is right we’ve been arguing during the pregnancy a lot .After the break up I kept ringing him and telling him I will change.I am in love with this guy and he is the best guy I have ever been with.I’m still hurt and in disbelief when he said he didn’t have any romantic feelings towards me anymore that hurt me faster than a lethal syringe.He texts me now and then mainly to check up on how am doing with the pregnancy,he is supportive with it but it’s not fair on me, him texting me as I just want to grieve the pain and not have any stress due to the pregnancy.i was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a spell for me. 28 hours later, my bf came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my bf are living together happily again.. All thanks to Dr Unity. If you have any problem contact Dr.Unity now and i guarantee you that he will help you.Email him at: Unityspelltemple@gmail.com ,you can also call him or add him on whats-app: +2348071622464 ,His website: http://unityspelltemple.yolasite.com .
Guest
2016-11-09 13:06:30 +0100
Getting ex boyfriend back after a breakup,I’m extremely happy that will are living together again. Am Maria 21yr from England, my boyfriend of a 4yr just broke up with me and am 30 weeks pregnant.I have cried my self to sleep most of the nights and don’t seem to concentrate during lectures sometimes I stay awake almost all night thinking about him and start to cry all over again.Because of this I end up not having energy for my next day’s classes ,my attendance has dropped and am always in uni and on time.Generally he is a very nice guy ,he ended it because he said we were arguing a lot and not getting along.He is right we’ve been arguing during the pregnancy a lot .After the break up I kept ringing him and telling him I will change.I am in love with this guy and he is the best guy I have ever been with.I’m still hurt and in disbelief when he said he didn’t have any romantic feelings towards me anymore that hurt me faster than a lethal syringe.He texts me now and then mainly to check up on how am doing with the pregnancy,he is supportive with it but it’s not fair on me, him texting me as I just want to grieve the pain and not have any stress due to the pregnancy.i was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr Unity can help solve marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a spell for me. 28 hours later, my bf came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my bf are living together happily again.. All thanks to Dr Unity. If you have any problem contact Dr.Unity now and i guarantee you that he will help you.Email him at: Unityspelltemple@gmail.com ,you can also call him or add him on whats-app: +2348071622464 ,His website: http://unityspelltemple.yolasite.com .
Guest
2016-11-04 02:41:44 +0100
Wow i never thought i will happy in my life ever again, i want you all to thank DR OGUDUGU of GREATOGUDUGU@GMAIL.COM, he is a father that takes care of his children the spell caster of our time, he has saved me from a very ugly situation that almost made my life miserable and i want you all to thank him for me,my husband and i have be married for so many years now with children and the relationship was being threatened by a small girl in his working place,she was almost destroying my home i met so many spell casters but to no avail until i met a friend who came from africa and she told me about DR OGUDUGU, and i decided to contact him and try him out as i was losing faith in all spell casters, but he told not to worry that now am in his temple everything will be alright he assured me 100% that his spell has no side effects and that it will work straight and save my home and my marriage and after he has performed the sacrifices and casted the spell, my husband came back to us with love and affection and he loved us more and more and he never looked back or none did his love for me waiver, if you are also experiencing this sort of your situation in your home, if your husband is drifting away, if you are experiencing a broken home or you have lost your husband to a young woman outside there then look no further help is here as GREATOGUDUGU@GMAIL.COM is ready to help you out okay for any of your problem is it financial needs, revenge spell,Hiv cure, job spell, promotion spell what kind of spell do you need DR OGUDUGU is going to solve it for you okay i have promised him to always talk of his good works to the world in general and to any body who cares to listen, you can email him on his personal email on GREATOGUDUGU@GMAIL.COM or his website @ www.greatdrogudugusolutiontemple.webs.com and he will attend to you as soon as possible okay once again his email is GREATOGUDUGU@GMAIL.COM.
Guest
2016-10-08 14:26:04 +0200
Thank you for your miracle Doctor Osemu Okpamen This article is dedicated to the Doctor Osemu Okpamen. I have been married with my wife for 5 years and recently she broke up with me and it hurt me deeply when she told me to leave her alone and that she does not love me anymore when i was always faithful and honest to her. I tried all the ways to get her back buying her what she wants like i always did and she still left me heart broken and she even has a new boyfriend which destroyed me even more until a friend of mine from high school directed me to this genuine spell Doctor called Osemu Okpamen. This man changed my life completely. I followed everything he told me to do and my wife came back begging for me back. I was stunned everything happened exactly like he told me. I had faith in everything he told me and everything was true. Also he was there every moment until i got my happiness back and he also provides spells that cures any diseases and sickness. You could contact him via email at { Doctorokpamenspelltemple@yahoo.com } or visit his website http://www.doctorokpamenspells.com or reach him on +1 (914)-517-3229. He will help you in anything you need and quick to answer once you contact him.
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