- Central European Biotechnology Portal
be visible on the BioBusiness market                  ISSN 2300-0228

Vintafolide - a chance for Platinum-Resistant Ovarian Cancer treatment.

Publish date: 2013-11-12

Merck, one of the leaders in production of pharmaceuticals, put its new medicine under review. It is called vintafolide, MK-8109 and it is an injectable drug conjugate consisting of folate (vitamin B9) linked to alkaloid chemotherapy agent, desacetylvinblastine monohydrazine (DAVLBH).

Tags: medicine , cancer , Merck , MSD , cancer targetting

Vintafolide is a water-soluble molecule designed to target the toxic vinblastine to the folate receptor, overexpressed in the case of certain cancers, including the ovarian one.  

DAVLBH is a derivative of the generated by plants vinblastine - vinca alkaloid, a chemical analogue of vincristine. Its action on the cells involves inhibition of assembling of microtubules, hindering the proper formation of the mitotic spindle and the kinetochore, necessary for mitosis process. Depending on the concentration it can suppress microtubule dynamics or polymer mass. Vintafolide utilizes the method of the Folate targeting to deliver the drug to cancer cells.   


The Phase II PRECEDENT trial involved the international study of 149 women with platinum-resistant ovarian cancer. Patients were receiving vintafolide plus pegylated liposomal doxorubicin (PLD) or PLD alone at a standard dose until the disease progression or death. The combination was well tolerated, no drug-related mortality was observed and the median progression-free survival (PFS) increased from 2.7 months to 5.0 months comparing to the PLD-alone treatment in the intent-to-treat (ITT) population.


MK-8109 is investigated in companion with diagnostic imaging agent etarfolatide (EC20), folate-receptor targeted. It allows identification of patients expressing the folate receptor and possibly responding to the vintafolide therapy.

Currently, it is being evaluated in a Phase III PROCEED clinical trial for platinum-resistant ovarian cancer. Moreover, Phase IIb TARGET trial for non-small cell lung cancer (NSCLC) is being executed. There are going to be performed also Phase II tests of vintafolide in folate receptor-positive triple negative breast cancer soon. Vintafolide along with PLD is under review of European Medicines Agency (EMA) and has already been granted orphan drug status in Europe in March 2012.

by Piotr Kołata









Add comment
2018-10-10 07:59:35 +0200
My ex left me with so much pains and since then i have been heart broken and shattered. I have contact many spell casters and they rip me off my money without any result. I have Emailed so many sites online looking for a good spell caster till i was directed by a 32years old woman who Dr Zuma has helped before, to contact Dr Zuma, i never believed him?but after i did as he directed my ex came back to me, told me to forgive her and i did and today am, or call him +2348164728160
2018-02-24 19:03:54 +0100
Buy Palbace Lemon Quaaludes,BOTOX,XANAX,VA, We have medications for the treatment of chronic back pains, cough, anxiety,panic disorder, depression, erectile dysfunction, dysfunction,adhd,narcolepsy, obesity,depression, fatigue,Weight Loss supplement and more online (no prescription required).We sell quality medications online at affordable and discount prices. Fast and secure overnight delivery. We are ready to sell minimum quantities and large supplies of our product worldwide (SHIPPING IS WORLDWIDE). Below is a list of some of our product : Klonopin 1mg,2mg Ativan Opama 10mg,20mg,30mg,40mg Ambien Soma 350mg Oxycotin Hydrocodone Roxicodone Percocert Lorazepam 2.5 mg (Ativan) Clonazepam 2 mg (Rivotril) Valium 2mg,5mg and 10mg Fentalyn patches Tramadol (Ultram) 50mg etc........ We offer: - Good quality Medications - Good and affordable prices. - Fast and Reliable delivery -Tracking Available! -Tracking numbers available with references. - Various shipping option (Overnight and Airmail). -Shipping secure and discreet ,Delivery time OVERNIGHT & 1-5 days depending on location. - Buy with and without Prescription Required! -Additional Discounts on Bulk Orders - Buy Direct and Save Time and Money! - 100% Customer Satisfaction Guaranteed ! Contact via details below: CONTACT NUMBER...9046868791
2016-04-03 05:45:58 +0200
My name is Jessica Luis, and I base in USA...My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr Mohammed, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mohammed's e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr Mohammed, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try High anytime, he might be the answer to your problems. Here's his contact: or call him +2348134493948
2016-04-03 03:52:56 +0200
'After being in relationship with Wilson for seven years,he broke up with me, I did everything possible to bring him back but all was in vain, I wanted him back so much because of the love I have for him, I begged him with everything, I made promises but he refused. I explained my problem to someone online and she suggested that I should contact a spell caster that could help me cast a spell to bring him back but I am the type that don't believed in spell, I had no choice than to try it, I meant a spell caster called Dr Zuma zuk and I email him, and he told me there was no problem that everything will be okay before three days, that my ex will return to me before three days, he cast the spell and surprisingly in the second day, it was around 4pm. My ex called me, I was so surprised, I answered the call and all he said was that he was so sorry for everything that happened, that he wanted me to return to him, that he loves me so much. I was so happy and went to him, that was how we started living together happily again. Since then, I have made promise that anybody I know that have a relationship problem, I would be of help to such person by referring him or her to the only real and powerful spell caster who helped me with my own problem and who is different from all the fake ones out there. Anybody could need the help of the spell caster, his email: or call him +2349055637784 you can email him if you need his assistance in your relationship or anything. CONTACT HIM NOW FOR SOLUTION TO ALL YOUR PROBLEMS'
See also
Cormay co. was granted for the greatest success and the best future perspectives among other co-partnerships in... Read more
Tags: poland , medicine
We are all alike – one could say when it comes to general features of people all around the world. Our general ... Read more
Tags: pharma , medicine
In 2012, for the first time, Poland will be the host of the first edition of the prestigious Prix Galien intern... Read more
Tags: pharma , medicine , events